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Xiao-Mei Shi
Researcher at University of Toronto
Publications - 15
Citations - 2670
Xiao-Mei Shi is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 12, co-authored 15 publications receiving 2557 citations.
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Journal ArticleDOI
Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.
Philip A. Marsden,Henry H.Q. Heng,Stephen W. Scherer,R. J. Stewart,A Hall,Xiao-Mei Shi,Lap-Chee Tsui,Keith T. Schappert +7 more
TL;DR: Characterization of 5'-flanking genomic regions indicates that the endothelial NO synthase promoter is "TATA-less" and exhibits proximal promoter elements consistent with a constitutively expressed gene that is found in endothelial cells, namely Sp1 and GATA motifs.
Journal ArticleDOI
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
Brian F. O'Dowd,Michael Heiber,Audrey Chan,Henry H.Q. Heng,Lap-Chee Tsui,James L. Kennedy,Xiao-Mei Shi,Arturas Petronis,Susan R. George,Tuan V. Nguyen +9 more
TL;DR: PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluorescence in situ hybridization (FISH) sublocalized APJ on band q12.
Journal ArticleDOI
Cloning and Chromosomal Mapping of Three Novel Genes, GPR9, GPR10, and GPR14, Encoding Receptors Related to Interleukin 8, Neuropeptide Y, and Somatostatin Receptors
Adriano Marchese,Michael Heiber,Tuan V. Nguyen,Henry H.Q. Heng,Victor Saldivia,Regina Cheng,Philip M. Murphy,Lap-Chee Tsui,Xiao-Mei Shi,Paul Gregor,Susan R. George,Brian F. O'Dowd,John Docherty +12 more
TL;DR: The polymerase chain reaction and genomic DNA library screening was employed to clone novel human genes, GPR9 and GPR10, and a rat gene, G PR14, which encode G protein-coupled receptors that share the highest identity with human IL-8 receptor type B.
Journal ArticleDOI
Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors
Adriano Marchese,John Docherty,Tuan V. Nguyen,Michael Heiber,Regina Cheng,Henry H.Q. Heng,Lap-Chee Tsui,Xiao-Mei Shi,Susan R. George,Brian F. O'Dowd +9 more
TL;DR: The isolation and characterization of several novel human genes encoding G protein-coupled receptors showed identity with a previously characterized cDNA clone from rat and was localized to chromosome 1p35-p36.
Journal ArticleDOI
The Cloning and Chromosomal Mapping of Two Novel Human Opioid-Somatostatin-like Receptor Genes, GPR7 and GPR8, Expressed in Discrete Areas of the Brain
Brian F. O'Dowd,Mark A. Scheideler,Tuan V. Nguyen,Regina Cheng,Jesper Skou Rasmussen,Adriano Marchese,Roman L. Zastawny,Henry H.Q. Heng,Lap-Chee Tsui,Xiao-Mei Shi,Sylvia L. Asa,Libertad A. Puy,Susan R. George +12 more
TL;DR: Following the cloning of the opioid receptors mu, kappa, and delta, a search for related receptors was conducted using oligonucleotides based on the opioid and also the structurally related somatostatin receptors and isolated fragments of novel G protein-coupled receptor genes named GPR7 and GPR8, which shared 70% identity with each other.