B
Brian Guy
Researcher at Johns Hopkins University
Publications - 2
Citations - 123
Brian Guy is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Organoid. The author has an hindex of 1, co-authored 2 publications receiving 58 citations.
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Journal ArticleDOI
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.
Amirhossein Ghanbari Niaki,Jaya Sarkar,Xinyi Cai,Kevin Rhine,Velinda Vidaurre,Brian Guy,Miranda N Hurst,Jong-Chan Lee,Hye Ran Koh,Hye Ran Koh,Lin Guo,Lin Guo,Charlotte M. Fare,James Shorter,Sua Myong,Sua Myong +15 more
TL;DR: It is demonstrated that wild-type FUS binds single-stranded RNA stoichiometrically in a length-dependent manner and that multimers induce highly dynamic interactions with RNA, giving rise to small and fluid condensates.
Journal ArticleDOI
Human neural organoids: Models for developmental neurobiology and disease.
TL;DR: A review of human neural organoid systems, how they are generated, advances in 3D imaging and bioengineering, and the impact of organoid studies on our understanding of the human nervous system can be found in this paper.