Kevin Rhine

TL;DR: It is demonstrated that wild-type FUS binds single-stranded RNA stoichiometrically in a length-dependent manner and that multimers induce highly dynamic interactions with RNA, giving rise to small and fluid condensates.

TL;DR: It is demonstrated that ALS/FTLD-linked FUS mutations in glycine (G) strikingly drive formation of droplets that do not readily interact withWT FUS, whereas arginine (R) mutants form mixed condensates with WT FUS.

TL;DR: In this paper, the authors present single-molecule and accompanying ensemble methods to quantify the nucleation, condensation, and maturation of ribonucleoprotein condensates more comprehensively.

TL;DR: This work reviews recent literature highlighting how RNA molecules seed proteinaceous granules, the mechanisms of healthy turnover of RNA granules in cells, which biophysical properties underly a transition to solid- or gel-like material states, and why persistent granules disrupt the cellular homeostasis of neurons.