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Brian K. Theisen
Researcher at University of Pittsburgh
Publications - 10
Citations - 1718
Brian K. Theisen is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Cancer & Internal medicine. The author has an hindex of 6, co-authored 8 publications receiving 1624 citations. Previous affiliations of Brian K. Theisen include University of Michigan.
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Journal ArticleDOI
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Ömer H. Yilmaz,Riccardo Valdez,Brian K. Theisen,Wei Guo,David O. Ferguson,Hong Wu,Sean J. Morrison +6 more
TL;DR: Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to depletecancer stem cells without damaging normalstem cells.
Journal ArticleDOI
Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation
Takao Hinoi,Aytekin Akyol,Brian K. Theisen,David O. Ferguson,Joel K. Greenson,Bart O. Williams,Kathleen R. Cho,Eric R. Fearon +7 more
TL;DR: The mouse model of colon-preferential gene targeting described here should facilitate efforts to define novel factors and mechanisms contributing to human colon tumor pathogenesis, as well as work on tumor-promoting environmental factors and agents and strategies for cancer prevention and treatment.
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Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
William Giblin,Monalisa Chatterji,Gerwin Westfield,Tehmina Masud,Brian K. Theisen,Hwei Ling Cheng,Hwei Ling Cheng,Jeffrey DeVido,Frederick W. Alt,Frederick W. Alt,David O. Ferguson,David G. Schatz,David G. Schatz,JoAnn Sekiguchi +13 more
TL;DR: In vivo evidence is provided that implicates aberrant RAG1/2 activity in lymphoid tumor development and premature immunosenescence and the immune system in this fully in vivo setting is provided.
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Tpp1/Acd maintains genomic stability through a complex role in telomere protection.
Tobias Else,Brian K. Theisen,Yipin Wu,Janna Hutz,Catherine E. Keegan,Gary D. Hammer,David O. Ferguson +6 more
TL;DR: The studies show that Tpp1/Acd plays a vital role in telomere protection, but likely has additional functions yet to be defined, as well as uncovering a striking pattern; fusions with telomeric sequences involve nonhomologous chromosomes while those lacking telomeral sequences involve homologues.
Journal ArticleDOI
Molecular Diagnostics in the Evaluation of Pancreatic Cysts.
TL;DR: The current management guidelines for pancreatic cysts, their underlying genetics, and the integration of molecular testing in cyst classification and prognostication are discussed.