B
Brian Kwok
Researcher at BC Cancer Research Centre
Publications - 11
Citations - 754
Brian Kwok is an academic researcher from BC Cancer Research Centre. The author has contributed to research in topics: Gene & Desmoplastic small-round-cell tumor. The author has an hindex of 7, co-authored 11 publications receiving 671 citations. Previous affiliations of Brian Kwok include University of British Columbia & Royal Tropical Institute.
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Journal ArticleDOI
The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Gabriel Leprivier,Marc Remke,Marc Remke,Barak Rotblat,Adrian M. Dubuc,Abigail Rachele F. Mateo,Marcel Kool,Sameer Agnihotri,Amal El-Naggar,Bin Yu,Syam Prakash Somasekharan,Brandon Faubert,Gaëlle Bridon,Cristina E. Tognon,Joan Mathers,Ryan Thomas,Amy Li,Adi Barokas,Brian Kwok,Mary Bowden,Stephanie Smith,Xiaochong Wu,Andrey Korshunov,Thomas Hielscher,Paul A. Northcott,Jason D. Galpin,Christopher A. Ahern,Ye Wang,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Russell G. Jones,Michael Pollak,Olivier Delattre,Martin E. Gleave,Eric Jan,Stefan M. Pfister,Stefan M. Pfister,Christopher G. Proud,W. Brent Derry,Michael D. Taylor,Poul H. Sorensen +41 more
TL;DR: It is reported that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Journal ArticleDOI
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization.
Mohhamed Qadir,Brian Kwok,Wieslawa H. Dragowska,K. H. To,D. Le,Marcel B. Bally,Sharon M. Gorski +6 more
TL;DR: It is suggested that autophagy knockdown may be useful in a combination therapy setting to sensitize breast cancer cells, including tamoxifen-resistant breast cancer Cells, to tamoxIFen therapy.
Journal ArticleDOI
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
Barak Rotblat,Amber L. Southwell,Dagmar E. Ehrnhoefer,Niels H. Skotte,Martina Metzler,Sonia Franciosi,Gabriel Leprivier,Syam Prakash Somasekharan,Adi Barokas,Yu Deng,Tiffany Tang,Joan Mathers,Naniye Malli Cetinbas,Mads Daugaard,Brian Kwok,Liheng Li,Christopher J. Carnie,Dieter Fink,Roberto Nitsch,Jason D. Galpin,Christopher A. Ahern,Gerry Melino,Gerry Melino,Josef M. Penninger,Michael R. Hayden,Poul H. Sorensen +25 more
TL;DR: The tumor suppressor HACE1 plays a role in the NRF2 antioxidative stress response pathway and in neurodegeneration, and is found to be essential for optimalNRF2 activation in cells challenged with oxidative stress.
Journal ArticleDOI
Pre-Existing Isoniazid Resistance, but Not the Genotype of Mycobacterium Tuberculosis Drives Rifampicin Resistance Codon Preference in Vitro
Indra Bergval,Brian Kwok,A. R. J. Schuitema,Kristin Kremer,Dick van Soolingen,Paul R. Klatser,Richard M. Anthony +6 more
TL;DR: It is concluded that, against specific genetic backgrounds, certain resistance mutations are particularly likely to spread and isolates are screened for the distribution of resistance mutations, especially in regions that are highly endemic for (multi)drug resistant tuberculosis.
Journal ArticleDOI
ChildSeq-RNA: A next-generation sequencing-based diagnostic assay to identify known fusion transcripts in childhood sarcomas.
Mohammed A. Qadir,Shing Hei Zhan,Brian Kwok,Jeremy Bruestle,Becky Drees,Oana Popescu,Poul H. Sorensen,Poul H. Sorensen +7 more
TL;DR: This proof-of-concept study proposes ChildSeq-RNA as a novel tool to detect gene fusions in childhood sarcomas at single-nucleotide resolution and develops a bioinformatics tool that operates on a scalable, cloud-computing platform.