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Sameer Agnihotri
Researcher at University of Toronto
Publications - 92
Citations - 4336
Sameer Agnihotri is an academic researcher from University of Toronto. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 26, co-authored 56 publications receiving 3582 citations. Previous affiliations of Sameer Agnihotri include Princess Margaret Cancer Centre.
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Journal ArticleDOI
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
Amparo Wolf,Sameer Agnihotri,Johann Micallef,Joydeep Mukherjee,Nesrin Sabha,Rob A. Cairns,Cynthia Hawkins,Abhijit Guha,Abhijit Guha +8 more
TL;DR: In glioblastoma multiforme, the most common adult primary brain tumor, the glycolytic enzyme hexokinase 2 facilitates growth and therapeutic resistance.
Journal ArticleDOI
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Stephen C. Mack,Hendrik Witt,Rosario M. Piro,L. Gu,Scott Zuyderduyn,Adrian M. Stütz,Xin Wang,Marco Gallo,Livia Garzia,Kory Zayne,Xiaoyang Zhang,Vijay Ramaswamy,Natalie Jäger,David T.W. Jones,Martin Sill,T. J. Pugh,Marina Ryzhova,Khalida Wani,David Shih,Renee Head,Marc Remke,Swneke D. Bailey,Thomas Zichner,Claudia C. Faria,Mark Barszczyk,Sebastian Stark,Huriye Seker-Cin,Sonja Hutter,Pascal Johann,Sebastian Bender,Volker Hovestadt,Theophilos Tzaridis,Adrian M. Dubuc,Paul A. Northcott,John Peacock,Kelsey C. Bertrand,Sameer Agnihotri,Florence M.G. Cavalli,Ian D. Clarke,K. Nethery-Brokx,Caretha L. Creasy,Sharad K. Verma,Jan Koster,Xiaochong Wu,Yuan Yao,Till Milde,Patrick Sin-Chan,Jennifer Zuccaro,Loretta Lau,Sergio L. Pereira,Pedro Castelo-Branco,Martin Hirst,Marco A. Marra,Stephen S. Roberts,Daniel W. Fults,Luca Massimi,Yoon Jae Cho,T. Van Meter,Wiesława Grajkowska,Boleslaw Lach,Andreas E. Kulozik,A. von Deimling,Olaf Witt,Stephen W. Scherer,Xing Fan,Karin M. Muraszko,Marcel Kool,Scott L. Pomeroy,Nalin Gupta,Joanna J. Phillips,Annie Huang,Uri Tabori,Cynthia Hawkins,David Malkin,Paul Kongkham,William A. Weiss,Nada Jabado,James T. Rutka,Eric Bouffet,Jan O. Korbel,Mathieu Lupien,Kenneth Aldape,Gary D. Bader,Roland Eils,Peter Lichter,Peter B. Dirks,Stefan M. Pfister,Andrey Korshunov,Michael D. Taylor +88 more
TL;DR: It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
Journal ArticleDOI
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Pawel Buczkowicz,Christine M. Hoeman,Patricia Rakopoulos,Sanja Pajovic,Louis Letourneau,Misko Dzamba,Andrew Morrison,Peter W. Lewis,Eric Bouffet,Ute Bartels,Jennifer Zuccaro,Sameer Agnihotri,Scott Ryall,Mark Barszczyk,Yevgen Chornenkyy,Mathieu Bourgey,Guillaume Bourque,Alexandre Montpetit,Francisco Cordero,Pedro Castelo-Branco,Joshua Mangerel,Uri Tabori,King Ching Ho,Annie Huang,Kathryn R. Taylor,Alan Mackay,Anne Bendel,Javad Nazarian,Jason Fangusaro,Matthias A. Karajannis,David Zagzag,Nicholas K. Foreman,Andrew M. Donson,Julia V Hegert,Amy Smith,Jennifer A. Chan,Lucy Lafay-Cousin,Sandra E. Dunn,Juliette Hukin,Chris Dunham,Katrin Scheinemann,Jean Michaud,Shayna Zelcer,David A. Ramsay,Jason E. Cain,Cameron Brennan,Mark M. Souweidane,Chris Jones,C. David Allis,Michael Brudno,Michael Brudno,Oren J. Becher,Cynthia Hawkins +52 more
TL;DR: This work integrated whole-genome sequencing with methylation, expression and copy number profiling, discovering that DIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPG.
Journal ArticleDOI
The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Gabriel Leprivier,Marc Remke,Marc Remke,Barak Rotblat,Adrian M. Dubuc,Abigail Rachele F. Mateo,Marcel Kool,Sameer Agnihotri,Amal El-Naggar,Bin Yu,Syam Prakash Somasekharan,Brandon Faubert,Gaëlle Bridon,Cristina E. Tognon,Joan Mathers,Ryan Thomas,Amy Li,Adi Barokas,Brian Kwok,Mary Bowden,Stephanie Smith,Xiaochong Wu,Andrey Korshunov,Thomas Hielscher,Paul A. Northcott,Jason D. Galpin,Christopher A. Ahern,Ye Wang,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Russell G. Jones,Michael Pollak,Olivier Delattre,Martin E. Gleave,Eric Jan,Stefan M. Pfister,Stefan M. Pfister,Christopher G. Proud,W. Brent Derry,Michael D. Taylor,Poul H. Sorensen +41 more
TL;DR: It is reported that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Journal ArticleDOI
Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies.
Sameer Agnihotri,Kelly Burrell,Amparo Wolf,Sharzhad Jalali,Cynthia Hawkins,James T. Rutka,Gelareh Zadeh +6 more
TL;DR: A brief history of the disease, current molecular knowledge, lessons from animal models and emerging concepts of angiogenesis, invasion, and metabolism in GBM that may lend themselves to therapeutic targeting are summarized.