Brian P. James

TL;DR: Single-agent vemurafenib did not show meaningful clinical activity in patients with BRAF V600E mutant CRC, and combination strategies are now under development and may be informed by the presence of intratumor heterogeneity of KRAS and NRAS mutations.

TL;DR: The study reveals a previously unrecognized function of EGFR in miRNA maturation and demonstrates how EGFR is likely to function as a regulator of AGO2 through novel post-translational modification, suggesting that modulation of miRNA biogenesis is important for stress response in tumour cells and has potential clinical implications.

TL;DR: It is suggested that increased HIF-1α produced by hypoxic tumors triggers the desmoplasic reaction in pancreatic cancer, which is then amplified by a feed forward loop involving cycles of decreased blood flow and increased hypoxia.

TL;DR: The findings point to a tumor suppressor role for ETS2 in human NSCLC pathogenesis through inhibition of the MET proto-oncogene.

TL;DR: It is demonstrated that nutrient stress caused by glutamine deprivation drives epithelial-mesenchymal transition (EMT) and aggressive behaviors in PDAC cells through up-regulation of the EMT master regulator Slug.