Bruce Cornell

TL;DR: In this article, the authors describe the development of a biosensing technique in which the conductance of a population of molecular ion channels is switched by the recognition event, which mimics biological sensory functions and can be used with most types of receptor, including antibodies and nucleotides.

TL;DR: In this paper, a tethered bilayer membrane (tBLM) was formed onto a gold electrode such that a well-defined ionic reservoir exists between the gold surface and the bilayer membranes.

TL;DR: It is used as a model for the interactions of the polypeptide segments of transmembrane proteins within the hydrocarbon region of the lipid bilayers of biomembrane structures and the various results are discussed to provide insight pertinent to the organisation, interactions, aggregation properties, boundary layer and packing arrangements of helicalpolypeptides and proteins in reconstituted systems and natural biomemBRanes.

TL;DR: Ten analogues of the 26-residue, bee venom peptide, melittin were synthesized, each with 13C enrichment of a single peptide carbonyl carbon, and it was evident that the peptide was well-aligned in the bilayers and reoriented about the bilayer normal.

TL;DR: The results are consistent with the left-handed pipi(6.3) (LD) single-stranded helix observed for gramicidin A in sodium dodecyl sulfate micelles, and the width of the carbonyl resonances suggests a distribution of molecular geometries possibly resulting from a spread in the helix pitch and handedness.