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Bruce F. Scharschmidt
Researcher at University of California, San Francisco
Publications - 119
Citations - 5926
Bruce F. Scharschmidt is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Glycerol phenylbutyrate & Phenylbutyrate. The author has an hindex of 41, co-authored 119 publications receiving 5658 citations. Previous affiliations of Bruce F. Scharschmidt include Chiron Corporation.
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Journal ArticleDOI
A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis.
Laura N. Bull,van Eijk Mj,Ludmila Pawlikowska,Joseph DeYoung,J. A. Juijn,Liao M,Leo W.J. Klomp,Noureddine Lomri,Rolf M. F. Berger,Bruce F. Scharschmidt,Bruce F. Scharschmidt,A.S. Knisely,Roderick H. J. Houwen,Nelson B. Freimer +13 more
TL;DR: This gene, called FIC1, is the first identified human member of a recently described subfamily of P-type ATPases; ATP-dependent aminophospholipid transport is the previously described function of members of this subfamily.
Journal Article
Validation of a recording spectrophotometric method for measurement of membrane-associated Mg- and NaK-ATPase activity.
TL;DR: The coupled-enzyme assay required less membrane protein, showed less variability in duplicate samples, required half the time, and also yielded accurate values in brain, kidney, and heart tissue, which should find broad application in the study of membrane ATPase.
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Hepatic organic anion uptake in the rat.
TL;DR: The hepatic uptake of bilirubin, indocyanine green and ICG was studied in 350 anesthetized Sprague-Dawley rats to clarify the relationship of hepatic BR uptake to its overall transport from plasma to bile.
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Safety and Immunogenicity of HCV E1E2 Vaccine Adjuvanted with MF59 Administered to Healthy Adults
Sharon E. Frey,Michael Houghton,Stephen R. Coates,Sergio Abrignani,David Chien,Domenico Rosa,Piero Pileri,Ranjit Ray,Adrian M. Di Bisceglie,Paola Rinella,Heather Hill,Mark Wolff,Viola Schultze,Jang H. Han,Bruce F. Scharschmidt,Robert B. Belshe +15 more
TL;DR: The HCV E1E2 adjuvanted with MF59C vaccine was safe and generally well-tolerated at each of the 3 dosage levels and induced antibody and lymphoproliferative responses.
Journal ArticleDOI
Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure
Steven D. Lidofsky,Nathan M. Bass,Marie Csete Prager,Denna E. Washington,A. E. Read,Teresa L. Wright,Nancy L. Ascher,John P. Roberts,Bruce F. Scharschmidt,John R. Lake +9 more
TL;DR: Intracranial pressure monitoring represents a potentially important tool in the preoperative and intraoperative management of comatose patients with fulminant hepatic failure and warrants further study.