Bruce L. Miller

TL;DR: A substantial number of familial cases still remain without an obvious causal variant, suggesting the existence of other FTD genetic causes besides those currently screened in clinical routine, and 14 variants of unknown significance in other rarer FTD or amyotrophic lateral sclerosis genes that require further segregation and functional analysis.

TL;DR: This article examined verbal list memory in participants with pathology-confirmed or biomarker-supported diagnoses to clarify inconsistencies in comparative memory performance and found that AD participants showed more rapid forgetting than bvFTD, whereas behavioral-variant frontotemporal dementia participants would show a more dysexecutive pattern.

TL;DR: This work provides a proof-of-principle for the use of CRISPR-Cas9-mediated excision of the pathogenic C9orf72 repeat expansion as a therapeutic strategy in FTD/ALS.

TL;DR: It is suggested that measures of interpersonal warmth can provide important clinical information about changes in underlying brain networks, and help clinicians and clinical researchers better identify which bvFTD and svPPA patients are at greater risk for interpersonal disruption.

TL;DR: This work examined excitatory and inhibitory parameters of neuronal subpopulations and investigated their specific associations to regional tau and Aβ, measured by positron emission tomography (PET), in patients with AD to provide critical insights about potential mechanistic links between abnormal neural oscillations and cellular correlates of impaired excitatories and inhibitories.