Bruna O. Carvalho

TL;DR: A modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.

TL;DR: A new class of malaria vaccine formulation based on the use of malarial antigens and the innate immunity agonist FliC is proposed, which contains intrinsic adjuvant properties and enhanced ability to induce specific humoral and cellular immune responses when administered alone or in combination with other adjuvants.

TL;DR: Ex vivo adhesion assays with Pv-iE before and after maturation are used to demonstrate a higher binding potential of schizonts compared to other asexual stages, prompting a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv- iE sequestration.

TL;DR: The apparent lack of specific sequences types suggests that the P. falciparum transmission dynamics in the whole Amazon are probably different from any other endemic region studied and possibly interfere with the parasite's ability to efficiently diversify its variant gene repertoires.

TL;DR: It is proposed that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development and influence the systemic immune response to the parasite.