B
Bryan M. Turner
Researcher at University of Birmingham
Publications - 122
Citations - 17998
Bryan M. Turner is an academic researcher from University of Birmingham. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 61, co-authored 122 publications receiving 17333 citations.
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Journal ArticleDOI
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Xinsheng Nan,Huck-Hui Ng,Colin A. Johnson,Carol D. Laherty,Bryan M. Turner,Robert N. Eisenman,Adrian Bird +6 more
TL;DR: The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2, an abundant nuclear protein that is essential for mouse embryogenesis.
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MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.
Huck-Hui Ng,Yi Zhang,Brian Hendrich,Colin A. Johnson,Bryan M. Turner,Hediye Erdjument-Bromage,Paul Tempst,Danny Reinberg,Adrian Bird +8 more
TL;DR: The data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes.
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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
Dirk Schübeler,David M. MacAlpine,David Scalzo,Christiane Wirbelauer,Charles Kooperberg,Fred van Leeuwen,Daniel E. Gottschling,Laura P. O'Neill,Bryan M. Turner,Jeffrey J. Delrow,Stephen P. Bell,Mark Groudine +11 more
TL;DR: A genome-wide chromatin structure analysis in a higher eukaryote found a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of H3, and inactive genes being hypomethylated and deacetylation at the same residues.
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The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
Peter Jeppesen,Bryan M. Turner +1 more
TL;DR: In this paper, immunolabeled human and mouse metaphase chromosomes with antibodies specific for the acetylated isoforms of histone H4 were labeled in regions corresponding to conventional R bands (regions enriched in coding DNA), except for a single chromosome in female cells.
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HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
Stephen E. Rundlett,Andrew A. Carmen,Ryuji Kobayashi,Sergei Bavykin,Bryan M. Turner,Michael Grunstein +5 more
TL;DR: The characterized yeast histone deacetylase complexes demonstrate that histone acetylation state has a role in regulating both heterochromatic silencing and regulated gene expression.