Bryan S. Der

TL;DR: Electronic design automation principles from EDA are applied to enable increased circuit complexity and to simplify the incorporation of synthetic gene regulation into genetic engineering projects, and it is demonstrated that engineering principles can be applied to identify and suppress errors that complicate the compositions of larger systems.

TL;DR: This work introduces RNA‐seq as a powerful method for circuit characterization and debugging that overcomes the limitations of fluorescent reporters and scales to large systems composed of many parts.

TL;DR: DNAplotlib supports improved communication of genetic design information and offers new avenues for static, interactive and dynamic visualizations that map and explore the links between the structure and function of genetic parts, devices and systems; including metabolic pathways and genetic circuits.

TL;DR: Advances are presented that enable the complete encoding of an electronic chip in the DNA carried by Escherichia coli, an exemplar of design automation pushing engineering beyond that achievable “by hand”, essential for realizing the potential of biology.

TL;DR: This work provides a starting point for a growing set of biodesign automation tools to tackle new synthesis challenges in a unified way and will enable direct comparison of new approaches, results that are transferable and standardized, and research into independent areas of the problem formulation with a clear path toward future integration.