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Byron L. Lam
Researcher at University of Miami
Publications - 325
Citations - 9601
Byron L. Lam is an academic researcher from University of Miami. The author has contributed to research in topics: Visual acuity & Optic nerve. The author has an hindex of 45, co-authored 303 publications receiving 8118 citations. Previous affiliations of Byron L. Lam include University of Iowa & University of Illinois at Chicago.
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Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
TL;DR: The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.
Journal ArticleDOI
Positional cloning of a novel gene on chromosome 16q causing Bardet–Biedl syndrome (BBS2)
Darryl Y. Nishimura,Charles Searby,Rivka Carmi,Khalil Elbedour,Lionel Van Maldergem,Anne B. Fulton,Byron L. Lam,Berkley R. Powell,Ruth E. Swiderski,Kevin Bugge,Neena B. Haider,Anne E. Kwitek-Black,Lihua Ying,David Duhl,Susan W. Gorman,Elise Héon,Alessandro Iannaccone,Dominique Bonneau,Leslie G. Biesecker,Samuel G. Jacobson,Edwin M. Stone,Val C. Sheffield +21 more
TL;DR: Mutation screening of a novel gene (BBS2) with a wide pattern of tissue expression revealed homozygous mutations in two inbred pedigrees, including the large Bedouin kindred used to initially identify the BBS2 locus.
Journal Article
An analysis of allelic variation in the ABCA4 gene
Andrew R. Webster,Elise Heon,Andrew J. Lotery,Kimberlie Vandenburgh,Thomas L. Casavant,Kean T. Oh,Gretel Beck,Gerald A. Fishman,Byron L. Lam,Alex Levin,John R. Heckenlively,Samuel G. Jacobson,Richard G. Weleber,Val C. Sheffield,Edwin M. Stone +14 more
TL;DR: The nucleotide diversity of the ABCA4 coding region, a collective measure of the number and prevalence of polymorphic sites in a region of DNA, was found to be 1.28, a value that is 9 to 400 times greater than that of two other macular disease genes that were examined in a similar fashion.
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Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP‐5‐IgG
Shelley A. Cross,Diva R. Salomao,Joseph E. Parisi,Thomas J. Kryzer,Elizabeth A. Bradley,Jonathan A. Mines,Byron L. Lam,Vanda A. Lennon +7 more
TL;DR: Positive serology obviates the need for vitreous biopsy and expedites the search for cancer, as CRMP‐5‐IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with Vitreous inflammatory cells.
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Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results.
William J. Feuer,Joyce C. Schiffman,Janet L. Davis,Vittorio Porciatti,Phillip Gonzalez,Rajeshwari D. Koilkonda,Huijun Yuan,Anil Lalwani,Byron L. Lam,John Guy +9 more
TL;DR: No serious safety problems were observed in the first 5 participants enrolled in this phase I trial of virus-based gene transfer in this mitochondrial disorder and additional study follow-up of these and additional participants planned for the next 4 years is needed to confirm these preliminary observations.