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Neena B. Haider
Researcher at Massachusetts Eye and Ear Infirmary
Publications - 87
Citations - 6745
Neena B. Haider is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Retinal & Retina. The author has an hindex of 33, co-authored 85 publications receiving 6279 citations. Previous affiliations of Neena B. Haider include Drexel University & University of Iowa.
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Journal ArticleDOI
Apoptosis in Myocytes in End-Stage Heart Failure
Jagat Narula,Neena B. Haider,Renu Virmani,Thomas G. DiSalvo,Frank D. Kolodgie,Roger J. Hajjar,U Schmidt,Marc J. Semigran,G W Dec,Ban-An Khaw +9 more
TL;DR: Loss of myocytes due to apoptosis occurs in patients with end-stage cardiomyopathy and may contribute to progressive myocardial dysfunction.
Journal ArticleDOI
Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
Jagat Narula,Pramod Pandey,Eloisa Arbustini,Neena B. Haider,Navneet Narula,Frank D. Kolodgie,Barbara Dal Bello,Marc J. Semigran,Anna Bielsa-Masdeu,G. William Dec,Sara Israels,Manel Ballester,Renu Virmani,Satya Saxena,Surender Kharbanda +14 more
TL;DR: In vivo evidence of cytochrome c-dependent activation of cysteine proteases in human cardiomyopathy supports the phenomenon of apoptosis in myopathic process.
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Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate
Neena B. Haider,Samuel G. Jacobson,Artur V. Cideciyan,Ruth E. Swiderski,Luan M. Streb,Charles Searby,Gretel Beck,Robin R. Hockey,David B. Hanna,Susan W. Gorman,David Duhl,Rivka Carmi,Jean Bennett,Richard G. Weleber,Gerald A. Fishman,Alan F. Wright,Edwin M. Stone,Val C. Sheffield +17 more
TL;DR: The results suggest that NR2E3 has a role in determining photoreceptor phenotype during human retinogenesis, and may be due to abnormal cone cell fate determination during retinal development.
Journal ArticleDOI
CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
Adrienne K. Mehalow,Shuhei Kameya,Richard S. Smith,Norman L. Hawes,James M. Denegre,James A. Young,Lesley S Bechtold,Neena B. Haider,Ulrich Tepass,John R. Heckenlively,Bo Chang,Jürgen K. Naggert,Patsy M. Nishina +12 more
TL;DR: Photoreceptor dysplasia and degeneration in Crb1 mutants strongly vary with genetic background, suggesting that the variability in phenotypes of human patients that carry mutations in CRB1 may be due to interactions with background modifiers in addition to allelic variations.
Journal ArticleDOI
Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death.
Frank D. Kolodgie,Jagat Narula,Allen P. Burke,Neena B. Haider,Andrew Farb,You Hui-Liang,John E. Smialek,Renu Virmani +7 more
TL;DR: Findings demonstrate extensive apoptosis of macrophages limited to the site of plaque rupture, and the proteolytic cleavage of caspase-1 in ruptured plaques suggests activation of this apoptotic precursor.