Matthew Vincent

TL;DR: The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.

TL;DR: Xian et al. as discussed by the authors applied single cell cloning to patient-matched endoscopic biopsies of Barrett's esophagus and coexisting lesions of low-grade dysplasia (LGD), high grade dysplastic (HGD), and esophageal adenocarcinoma (EAC) to identify drugs that would target the Barrett's stem cells for preemptive therapeutics.

TL;DR: Understanding the interplay giving rise to opposing pressures – one from an expanding elderly population to improve health in old age, and a growing concern for containing healthcare costs – will be critical to tissue and cell therapy companies as they plan for and address concerns about how patients can afford innovation in this important area of treatment.

TL;DR: Wang et al. as mentioned in this paper used single-cell cloning technologies to generate libraries of basal stem cells from the distal lungs of 16 patients with IPF and 10 controls, which they used to identify a major stem cell variant that was distinguished from normal stem cells by its ability to transform normal lung fibroblasts into pathogenic myofibroblast in vitro and to activate and recruit myofiberblasts in clonal xenografts.