C
C D Allis
Researcher at University of Virginia
Publications - 5
Citations - 11291
C D Allis is an academic researcher from University of Virginia. The author has contributed to research in topics: Histone code & Histone H1. The author has an hindex of 4, co-authored 5 publications receiving 10708 citations.
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.
Journal ArticleDOI
Code of silence.
TL;DR: Using genetic approaches and a filamentous fungus, molecular biologists have found further evidence of an intimate relationship between genomes and the histone proteins that evolved to package them.
Journal ArticleDOI
Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
TL;DR: The structural data indicate a single-step acetyl-transfer reaction mechanism catalysed by a hydrogen bond to the backbone amide group of leucine 126 and the side-chain carboxyl group of a conserved acidic residue.