C
C. Edward Hoffler
Researcher at University of Michigan
Publications - 6
Citations - 1208
C. Edward Hoffler is an academic researcher from University of Michigan. The author has contributed to research in topics: Bone tissue & Cortical bone. The author has an hindex of 5, co-authored 5 publications receiving 1106 citations.
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Journal ArticleDOI
Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur
TL;DR: In this paper, an isotropic elastic modulus was calculated from the unloading curve with an assumed Poisson ratio of 0.3, while hardness was defined as the maximal force divided by the corresponding contact area.
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An application of nanoindentation technique to measure bone tissue lamellae properties
TL;DR: The preliminary results indicated that interstitial bone tissue has significantly higher modulus and hardness than osteonal bone tissue and a significant correlation between hardness and elastic modulus was observed.
Journal ArticleDOI
Spatial distribution of phosphate species in mature and newly generated mammalian bone by hyperspectral Raman imaging
Jerilyn A. Timlin,Angela Carden,Michael D. Morris,Jeffrey Bonadio,C. Edward Hoffler,Kenneth M. Kozloff,Steven A. Goldstein +6 more
TL;DR: Hyperspectral Raman images of mineral components of trabecular and cortical bone at 3 μm spatial resolution are presented and uniform PO4-3 and HPO4-2 distribution is verified by spectral band integration.
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Novel Explant Model to Study Mechanotransduction and Cell-Cell Communication
C. Edward Hoffler,Kurt D. Hankenson,Joshua D. Miller,Sukhinderdeep K. Bilkhu,Steven A. Goldstein +4 more
TL;DR: This model may be useful in understanding osteocyte mechanotransduction in the context of a physiologically relevant bone matrix and demonstrated real‐time biologic activity of osteocytes while bending the bone matrix.