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Kenneth M. Kozloff

Researcher at University of Michigan

Publications -  99
Citations -  3477

Kenneth M. Kozloff is an academic researcher from University of Michigan. The author has contributed to research in topics: Osteogenesis imperfecta & Osteoblast. The author has an hindex of 31, co-authored 94 publications receiving 3020 citations. Previous affiliations of Kenneth M. Kozloff include Harvard University.

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Heterogeneity of bone lamellar-level elastic moduli.

TL;DR: Using nanoindentation, elastic modulus and hardness of human lamellar bone tissue is quantified as a function of tissue microstructures and anatomic location to suggest microstructural distinctions can vary with anatomical location.
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Extracellular matrix networks in bone remodeling.

TL;DR: This comprehensive review will focus on how networks of ECM proteins function to regulate osteoclast- and osteoblast-mediated bone remodeling and the clinical significance of these networks on normal bone and as they relate to pathologies of bone mass and geometry will be considered.
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Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.

TL;DR: In vivo evidence is provided that in arteries and aortic valves, macrophage burden and calcification associate with each other, whereas inflammation inversely correlates with bone mineralization, which provides insight into selective abrogation of divergent calcific phenomena.
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Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMD.

TL;DR: The results indicate that beam hardening artifacts of up to 32.6% can occur in sample sizes of interest in studies investigating mineralized tissue and affect mineral density measurements and that microCT can be an accurate tool for murine bone densitometry.
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Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength.

TL;DR: The Brtl mouse model for type IV osteogenesis imperfecta improves its whole bone strength and stiffness between 2 and 6 months of age without a corresponding improvement in geometric resistance to bending, suggesting an improvement in matrix material properties.