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X. Edward Guo
Researcher at Columbia University
Publications - 196
Citations - 13338
X. Edward Guo is an academic researcher from Columbia University. The author has contributed to research in topics: Quantitative computed tomography & Bone mineral. The author has an hindex of 61, co-authored 190 publications receiving 11855 citations. Previous affiliations of X. Edward Guo include University of Michigan & Harvard University.
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Journal ArticleDOI
Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur
TL;DR: In this paper, an isotropic elastic modulus was calculated from the unloading curve with an assumed Poisson ratio of 0.3, while hardness was defined as the maximal force divided by the corresponding contact area.
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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.
Vijay K. Yadav,Franck Oury,Nina Suda,Zhong-Wu Liu,Xiao-Bing Gao,Cyrille Confavreux,Kristen C. Klemenhagen,Kenji F. Tanaka,Kenji F. Tanaka,Jay A. Gingrich,X. Edward Guo,Laurence H. Tecott,J. John Mann,René Hen,Tamas L. Horvath,Gerard Karsenty +15 more
TL;DR: This study modifies the map of leptin signaling in the brain and identifies a molecular basis for the common regulation of bone and energy metabolisms.
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Engineering anatomically shaped human bone grafts
Warren L. Grayson,Mirjam Fröhlich,Keith Yeager,Sarindr Bhumiratana,M. Ete Chan,Christopher Cannizzaro,Leo Q. Wan,X. Sherry Liu,X. Edward Guo,Gordana Vunjak-Novakovic +9 more
TL;DR: It is reported that clinically sized, anatomically shaped, viable human bone grafts can be engineered by using human mesenchymal stem cells (hMSCs) and a “biomimetic” scaffold-bioreactor system to provide patient-specificBone grafts for craniofacial and orthopedic reconstructions.
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Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies.
Van C. Mow,X. Edward Guo +1 more
TL;DR: In this paper, the recent advances in cartilage biomechanics and electromechanics are reviewed and summarized, focusing on the new experimental and theoretical findings of cartilage mechanics.
MECHANO-ELECTROCHEMICAL PROPERTIES OF ARTICULAR CARTILAGE: Their Inhomogeneities
Van C. Mow,X. Edward Guo +1 more
TL;DR: The charged nature and depth-dependent inhomogeneity in mechano-electrochemical properties of articular cartilage are examined, and their importance in the normal and/or pathological structure-function relationships with cartilage is discussed, along with their pathophysiological implications.