C
C R Young
Researcher at University of Maryland, Baltimore
Publications - 21
Citations - 1577
C R Young is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Vibrio cholerae & Antitoxin. The author has an hindex of 17, co-authored 21 publications receiving 1526 citations. Previous affiliations of C R Young include University of Maryland, College Park.
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Journal ArticleDOI
Duration of Infection-Derived Immunity to Cholera
TL;DR: The impressive duration of infection-derived immunity suggests that the most promising approach to development of cholera vaccines may be to mimic natural immunity with orally administered, attenuated strains of V. cholerae.
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Coli surface antigens 1 and 3 of colonization factor antigen II-positive enterotoxigenic Escherichia coli: morphology, purification, and immune responses in humans.
Myron M. Levine,P A Ristaino,G Marley,Cyril J. Smyth,Stuart Knutton,Edgar C. Boedeker,Robert E. Black,C R Young,Mary Lou Clements,Christopher P. Cheney +9 more
TL;DR: Six of nine volunteers who developed diarrhea after challenge with an O139:H28 ETEC strain bearing CS1 and CS3 had significant serological rises to purified CS1, suggesting that both antigens are elaborated in vivo, play a role in pathogenesis, and stimulate an immune response.
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Immunity to Enterotoxigenic Escherichia coli
Myron M. Levine,David R. Nalin,David L. Hoover,Erick J. Bergquist,Richard B. Hornick,C R Young +5 more
TL;DR: These studies demonstrate that prior disease due to enterotoxigenic E. coli confers homologous immunity against subsequent challenge, and the operative mechanism apparently is not bactericidal and is not mediated by serum anti-O antibodies.
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Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin.
Robert E. Black,Myron M. Levine,Mary Lou Clements,C R Young,Ann-Mari Svennerholm,Jan Holmgren +5 more
TL;DR: The studies in human volunteers were successful in predicting the substantial protection afforded by the vaccines in a cholera endemic area, and a field efficacy trial is underway in Bangladesh.
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Evaluation in humans of attenuated Vibrio cholerae El Tor Ogawa strain Texas Star-SR as a live oral vaccine.
Myron M. Levine,Robert E. Black,Mary Lou Clements,Claudio F. Lanata,S D Sears,Takeshi Honda,C R Young,Richard A. Finkelstein +7 more
TL;DR: Texas Star-SR, an A- B+ mutant derived by nitrosoguanidine treatment from Vibrio cholerae El Tor Ogawa strain 3083, served as a prototype to investigate the concept of immunoprophylaxis by means of attenuated strains as oral vaccines.