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C. Roger White
Researcher at University of Alabama at Birmingham
Publications - 64
Citations - 4189
C. Roger White is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Nitric oxide & Apolipoprotein B. The author has an hindex of 28, co-authored 63 publications receiving 3912 citations. Previous affiliations of C. Roger White include University of Birmingham.
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Journal ArticleDOI
Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
Jason P. Eiserich,Stephan Baldus,Marie Luise Brennan,Wenxin Ma,Chunxiang Zhang,Albert Tousson,Laura Castro,Aldons J. Lusis,William M. Nauseef,C. Roger White,Bruce A. Freeman +10 more
TL;DR: Myeloperoxidase, an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions, can directly modulate vascular inflammatory responses by regulating NO bioavailability during acute inflammation.
Journal ArticleDOI
Biological aspects of reactive nitrogen species.
Rakesh P. Patel,Joanne McAndrew,Hassan Sellak,C. Roger White,Hanjoong Jo,Bruce A. Freeman,Bruce A. Freeman,Victor M. Darley-Usmar +7 more
TL;DR: This review will illustrate how, when specificity and amplification through cell signalling mechanisms are taken into account, the less significant reactions can explain many of the biological responses of exposure of cells or physiological systems to RNS.
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Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Mutay Aslan,Thomas M. Ryan,Brian Adler,Tim M. Townes,Dale A. Parks,J. Anthony Thompson,Albert Tousson,Mark T. Gladwin,Rakesh P. Patel,Margaret M. Tarpey,Ines Batinic-Haberle,C. Roger White,Bruce A. Freeman +12 more
TL;DR: Data reveal that episodes of intrahepatic hypoxia-reoxygenation associated with SCD can induce the release of XO into the circulation from the liver.
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Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration.
Stephan Baldus,Jason P. Eiserich,Alireza Mani,Laura Castro,Mario Figueroa,Phillip Chumley,Wenxin Ma,Albert Tousson,C. Roger White,Daniel C. Bullard,Marie Luise Brennan,Aldons J. Lusis,Kevin P. Moore,Bruce A. Freeman +13 more
TL;DR: It is shown that MPO concentrates in the subendothelial matrix of vascular tissues by a transcytotic mechanism and serves as a catalyst of ECM protein tyrosine nitration, and significantly contributes to NO(2)Tyr formation in vivo.
Journal ArticleDOI
Chemiluminescent Detection of Oxidants in Vascular Tissue: Lucigenin But Not Coelenterazine Enhances Superoxide Formation
TL;DR: Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite.