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William M. Nauseef
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 178
Citations - 18066
William M. Nauseef is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Myeloperoxidase & NADPH oxidase. The author has an hindex of 68, co-authored 170 publications receiving 16728 citations. Previous affiliations of William M. Nauseef include University of Iowa & United States Department of Veterans Affairs.
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Journal ArticleDOI
The neutrophil NADPH oxidase
TL;DR: The recent identification of homologs of one of the membrane components in nonphagocytic cells will expand understanding of the biological contexts in which this system may function.
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How human neutrophils kill and degrade microbes: an integrated view.
TL;DR: The importance and complexity of myeloperoxidase‐mediated events illustrate a collaboration of anti‐microbial responses that are endogenous to the neutrophil, whereas the synergy between the phagocyte NADPH and plasma‐derived group IIA phospholipase A2 exemplifies the collective effects of the neutophil with an exogenous factor to achieve degradation of ingested staphylococci.
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Neutrophils at work
TL;DR: This Review examines in vivo observations of the recruitment of neutrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through epithelial linings, and examines data on novel aspects of the activation of NADPH oxidase and the heterogeneity of phagosomes.
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Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
Jason P. Eiserich,Stephan Baldus,Marie Luise Brennan,Wenxin Ma,Chunxiang Zhang,Albert Tousson,Laura Castro,Aldons J. Lusis,William M. Nauseef,C. Roger White,Bruce A. Freeman +10 more
TL;DR: Myeloperoxidase, an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions, can directly modulate vascular inflammatory responses by regulating NO bioavailability during acute inflammation.
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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
Shankar S. Iyer,Qiong He,John R. Janczy,Eric I. Elliott,Zhenyu Zhong,Alicia K. Olivier,Jeffrey J. Sadler,Vickie Knepper-Adrian,Renzhi Han,Liang Qiao,Stephanie C. Eisenbarth,William M. Nauseef,Suzanne L. Cassel,Fayyaz S. Sutterwala +13 more
TL;DR: Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of NLRp3 to cardiolipin.