C
Caleb B. Kallen
Researcher at Lankenau Medical Center
Publications - 45
Citations - 3698
Caleb B. Kallen is an academic researcher from Lankenau Medical Center. The author has contributed to research in topics: Steroidogenic acute regulatory protein & Lung. The author has an hindex of 24, co-authored 44 publications receiving 3517 citations. Previous affiliations of Caleb B. Kallen include Thomas Jefferson University & University of Pennsylvania.
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Journal ArticleDOI
Differential activation of peroxisome proliferator-activated receptors by eicosanoids.
Ker Yu,William Bayona,Caleb B. Kallen,Heather P. Harding,Christina P. Ravera,Gerald McMahon,Myles Brown,Mitchell A. Lazar +7 more
TL;DR: Results indicate that PPARs are differentially activated by naturally occurring eicosanoids and related molecules.
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Phosphorylation of Steroidogenic Acute Regulatory Protein (StAR) Modulates Its Steroidogenic Activity
Futoshi Arakane,Steven R. King,Yang Du,Caleb B. Kallen,Lance P. Walsh,Hidemichi Watari,Douglas M. Stocco,Jerome F. Strauss +7 more
TL;DR: The observations suggest that phosphorylation of serine 194/195 increases the biological activity of StAR and that this post- or co-translational event accounts, in part, for the immediate effects of cAMP on steroid production.
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Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.
TL;DR: Results indicate that antidiabetic thiazolidinediones down-regulate leptin gene expression with potencies that correlate with their abilities to bind and activate PPARgamma.
Journal ArticleDOI
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis
Hidemichi Watari,Futoshi Arakane,Christel Moog-Lutz,Caleb B. Kallen,Catherine Tomasetto,George L. Gerton,Marie-Christine Rio,Michael E. Baker,Jerome F. Strauss +8 more
TL;DR: It is concluded that MLN64 stimulates steroidogenesis by virtue of its homology to StAR, which plays a key role in steroid hormone biosynthesis by enhancing the intramitochondrial translocation of cholesterol to the cholesterol side-chain cleavage enzyme.
Journal ArticleDOI
Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein.
Caleb B. Kallen,Jeffrey T. Billheimer,Scott A. Summers,Steven Stayrook,Mitchell Lewis,Jerome F. Strauss +5 more
TL;DR: The steroidogenic acute regulatory protein (StAR) plays a critical role in steroidogenesis by enhancing the delivery of substrate cholesterol from the outer mitochondrial membrane to the cholesterol side chain cleavage enzyme system on the inner membrane as discussed by the authors.