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Carina Brehony
Researcher at University of Oxford
Publications - 30
Citations - 1589
Carina Brehony is an academic researcher from University of Oxford. The author has contributed to research in topics: Meningococcal vaccine & Multilocus sequence typing. The author has an hindex of 15, co-authored 29 publications receiving 1354 citations. Previous affiliations of Carina Brehony include Health Service Executive & National University of Ireland, Galway.
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Journal ArticleDOI
Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain.
Keith A. Jolley,Carly M. Bliss,Julia S. Bennett,Holly B. Bratcher,Carina Brehony,Frances M. Colles,Helen M. L. Wimalarathna,Odile B. Harrison,Samuel K. Sheppard,Alison J. Cody,Martin C. J. Maiden +10 more
TL;DR: This work proposes ribosomal multilocus sequence typing (rMLST), an approach which indexes variation of the 53 genes encoding the bacterial ribosome protein subunits (rps genes), as a means of integrating microbial genealogy and typing, and employs curated reference sequences to identify gene variants efficiently and rapidly.
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Molecular typing of meningococci: recommendations for target choice and nomenclature
TL;DR: The diversity and dynamics of Neisseria meningitidis populations generate a requirement for high resolution, comprehensive, and portable typing schemes for meningococcal disease surveillance, and the following target genes are recommended.
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A surveillance network for meningococcal disease in Europe
Caroline Trotter,Manosree Chandra,R Cano,Amparo Larrauri,Mary Ramsay,Carina Brehony,Keith A. Jolley,Martin C. J. Maiden,Sigrid Heuberger,Matthias Frosch +9 more
TL;DR: A major decline in the incidence of invasive disease in those countries that have introduced routine vaccination against serogroup C infection is demonstrated and case fatality was found to vary with clonal complex, suggesting that genotype can be a marker for hypervirulence.
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Multilocus sequence typing for global surveillance of meningococcal disease
TL;DR: The 'Impact of meningococcal epidemiology and population biology on public health in Europe (EU-MenNet)' project has shown the distribution of a relatively small number of STs, clonal complexes and PorA types that account for a large proportion of the disease-associated isolates in Europe.
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Variation of the factor H-binding protein of Neisseria meningitidis.
TL;DR: A survey of the diversity of the fHbp gene and the encoded protein confirmed that variability in this protein is structured into two or three major groups, each with a substantial number of alleles that have some association with meningococcal clonal complexes and serogroups.