D
Daniel J. Wilson
Researcher at University of Oxford
Publications - 215
Citations - 18281
Daniel J. Wilson is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Coalescent theory. The author has an hindex of 72, co-authored 203 publications receiving 15494 citations. Previous affiliations of Daniel J. Wilson include University of Chicago & National Institute for Health Research.
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Journal ArticleDOI
Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study
Timothy M Walker,Camilla L. C. Ip,Ruth H. Harrell,Jason T. Evans,Georgia Kapatai,Martin Dedicoat,David W Eyre,Daniel J. Wilson,Peter M. Hawkey,Peter M. Hawkey,Derrick W. Crook,Julian Parkhill,David Harris,A. Sarah Walker,Rory Bowden,Philip Monk,E. Grace Smith,Tim E. A. Peto +17 more
TL;DR: The genetic diversity of related M tuberculosis strains in the UK Midlands is estimated and the technique could identify super-spreaders and predict the existence of undiagnosed cases, potentially leading to early treatment of infectious patients and their contacts.
Journal ArticleDOI
Transforming clinical microbiology with bacterial genome sequencing
Xavier Didelot,Rory Bowden,Rory Bowden,Rory Bowden,Daniel J. Wilson,Daniel J. Wilson,Tim E. A. Peto,Derrick W. Crook +7 more
TL;DR: It is predicted that the application of next-generation sequencing will soon be sufficiently fast, accurate and cheap to be used in routine clinical microbiology practice, where it could replace many complex current techniques with a single, more efficient workflow.
Journal ArticleDOI
ClonalFrameML: efficient inference of recombination in whole bacterial genomes.
Xavier Didelot,Daniel J. Wilson +1 more
TL;DR: This work uses maximum likelihood inference to simultaneously detect recombination in bacterial genomes and account for it in phylogenetic reconstruction and finds evidence for recombination hotspots associated with mobile elements in Clostridium difficile ST6 and a previously undescribed 310kb chromosomal replacement in Staphylococcus aureus ST582.
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Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
David W Eyre,Madeleine Cule,Daniel J. Wilson,David J. Griffiths,Alison Vaughan,Lily O’Connor,Ip Clc.,Tanya Golubchik,Elizabeth M. Batty,John Finney,David H. Wyllie,Xavier Didelot,Paolo Piazza,Rory Bowden,Kate E. Dingle,Rosalind M. Harding,Derrick W. Crook,Mark H. Wilcox,Peto Tea.,AS Walker +19 more
TL;DR: Genetically diverse sources, in addition to symptomatic patients, play a major part in C. difficile transmission, which suggests a considerable reservoir of C. Difficile infection identified in health care settings or in the community in Oxfordshire.
Journal ArticleDOI
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
Timothy M Walker,Thomas Kohl,Shaheed V. Omar,Jessica Hedge,Carlos del Ojo Elias,Phelim Bradley,Zamin Iqbal,Silke Feuerriegel,Katherine E. Niehaus,Daniel J. Wilson,David A. Clifton,Georgia Kapatai,Camilla L. C. Ip,Rory Bowden,Francis Drobniewski,Francis Drobniewski,Caroline Allix-Béguec,Cyril Gaudin,Julian Parkhill,Roland Diel,Philip Supply,Philip Supply,Derrick W. Crook,E. Grace Smith,A. Sarah Walker,Nazir Ahmed Ismail,Stefan Niemann,Tim E. A. Peto +27 more
TL;DR: A broad catalogue of genetic mutations enable data from whole-genome sequencing to be used clinically to predict drug resistance, drug susceptibility, or to identify drug phenotypes that cannot yet be genetically predicted.