F
Frances M. Colles
Researcher at University of Oxford
Publications - 59
Citations - 6251
Frances M. Colles is an academic researcher from University of Oxford. The author has contributed to research in topics: Campylobacter & Campylobacter jejuni. The author has an hindex of 32, co-authored 53 publications receiving 5695 citations. Previous affiliations of Frances M. Colles include National Institute for Health Research & American Society for Microbiology.
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Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
Journal ArticleDOI
Multilocus Sequence Typing System for Campylobacter jejuni
Kate E. Dingle,Frances M. Colles,David R. A. Wareing,Roisin Ure,Andrew J. Fox,F. E. Bolton,H. J. Bootsma,Rob J. L. Willems,Rachel Urwin,Martin C. J. Maiden +9 more
TL;DR: A multilocus sequence typing (MLST) system for this organism is described, which exploits the genetic variation present in seven housekeeping loci to determine the genetic relationships among isolates and indicates that C. jejuni is genetically diverse, with a weakly clonal population structure.
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Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain.
Keith A. Jolley,Carly M. Bliss,Julia S. Bennett,Holly B. Bratcher,Carina Brehony,Frances M. Colles,Helen M. L. Wimalarathna,Odile B. Harrison,Samuel K. Sheppard,Alison J. Cody,Martin C. J. Maiden +10 more
TL;DR: This work proposes ribosomal multilocus sequence typing (rMLST), an approach which indexes variation of the 53 genes encoding the bacterial ribosome protein subunits (rps genes), as a means of integrating microbial genealogy and typing, and employs curated reference sequences to identify gene variants efficiently and rapidly.
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Comparative Genotyping of Campylobacter jejuni by Amplified Fragment Length Polymorphism, Multilocus Sequence Typing, and Short Repeat Sequencing: Strain Diversity, Host Range, and Recombination
Leo M. Schouls,Sanne Reulen,Birgitta Duim,Jaap A. Wagenaar,Rob J. L. Willems,Kate E. Dingle,Frances M. Colles,Jan D. A. van Embden +7 more
TL;DR: Typing of Campylobacter strains is useful for identification of outbreaks but is probably not useful for source tracing and global epidemiology because of carriage of strains of multiple types and an extremely high diversity of strains in animals.
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Molecular characterization of Campylobacter jejuni clones: a basis for epidemiologic investigation.
Kate E. Dingle,Frances M. Colles,Roisin Ure,Jaap A. Wagenaar,Birgitta Duim,F. J. Bolton,Andrew J. Fox,David R. A. Wareing,Martin C. J. Maiden +8 more
TL;DR: The data demonstrate that the clonal complex, as defined by MLST, is an epidemiologically relevant unit for both long and short-term investigations of C. jejuni epidemiology, and several clonal complexes exhibited associations with isolation source or particular cell-surface components.