Carl Weidinger

TL;DR: An overview about TRP-mediated effects in immune and epithelial cells with an emphasis on mucosal immunology of the gut is provided and understanding of its molecular mechanisms paves the way to novel clinical approaches for the treatment of various inflammatory disorders including IBD.

TL;DR: The present review selected the four adipokines adiponectin, apelin, chemerin, and leptin and provides a working model based on the available literature how these factors participate in the maintenance of intestinal immune homeostasis.

TL;DR: The fundamental basis of intestinal T cell homing is summarized, the molecular groundwork underlying current and potential future anti-adhesion therapies are explained and the outlook to the future of anti-integrin antibodies and inhibitors is given.

TL;DR: In this article, the authors used qRT-PCR and immunohistochemistry to detect SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa and identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8+ T cells as well as epithelial apoptosis and subsequent regenerative proliferation.

TL;DR: In human and murine colonic epithelial cell lines, the presence of the HDAC inhibitors Givinostat and VorInostat not only improved transepithelial electrical resistance under inflammatory conditions but also attenuated the passage of macromolecules across the epithelial monolayer.