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Yasmina Rodriguez-Sillke
Researcher at Humboldt University of Berlin
Publications - 3
Citations - 81
Yasmina Rodriguez-Sillke is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Crohn's disease & Immune system. The author has an hindex of 2, co-authored 3 publications receiving 23 citations. Previous affiliations of Yasmina Rodriguez-Sillke include Charité.
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Journal ArticleDOI
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8 + T cells.
Malte Lehmann,Kristina Allers,Claudia Heldt,Jenny Meinhardt,Franziska Schmidt,Yasmina Rodriguez-Sillke,Yasmina Rodriguez-Sillke,Désirée Kunkel,Michael Schumann,Chotima Böttcher,Christiane Stahl-Hennig,Sefer Elezkurtaj,Christian Bojarski,Helena Radbruch,Victor M. Corman,Thomas Schneider,Christoph Loddenkemper,V. Moos,Carl Weidinger,Anja A. Kühl,Britta Siegmund +20 more
TL;DR: In this article, the authors used qRT-PCR and immunohistochemistry to detect SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa and identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8+ T cells as well as epithelial apoptosis and subsequent regenerative proliferation.
Journal ArticleDOI
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Jörn F. Ziegler,Jörn F. Ziegler,Chotima Böttcher,Marilena Letizia,Marilena Letizia,Cansu Yerinde,Cansu Yerinde,Hao Wu,Hao Wu,Inka Freise,Inka Freise,Yasmina Rodriguez-Sillke,Yasmina Rodriguez-Sillke,Ani K. Stoyanova,Martin E. Kreis,Patrick Asbach,Désirée Kunkel,Josef Priller,Josef Priller,Ioannis Anagnostopoulos,Ioannis Anagnostopoulos,Anja A. Kühl,Anja A. Kühl,Konstanze Miehle,Michael Stumvoll,Florian Tran,Broder Fredrich,Michael Forster,Andre Franke,Christian Bojarski,Christian Bojarski,Rainer Glauben,Rainer Glauben,Britt-Sabina Löscher,Britta Siegmund,Britta Siegmund,Carl Weidinger,Carl Weidinger +37 more
TL;DR: Evidence is provided that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade, ultimately aggravating Crohn’s disease in the AGLCD patient, which can be reversed by anti-TNFα therapy.
Journal ArticleDOI
Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can Be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab.
Bosse Jessen,Yasmina Rodriguez-Sillke,Elena Sonnenberg,Michael Schumann,Andrey Kruglov,Inka Freise,Franziska Schmidt,Jochen Maul,Anja A. Kühl,Rainer Glauben,D Lissner,Britta Siegmund +11 more
TL;DR: Production of a high level of TNF by PBMCs (specifically CD14+ cells) from patients with IBD can identify those most likely to have a clinical response to infliximab therapy.