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Claudia Heldt
Researcher at Humboldt University of Berlin
Publications - 5
Citations - 43
Claudia Heldt is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 2 publications receiving 2 citations.
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Journal ArticleDOI
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8 + T cells.
Malte Lehmann,Kristina Allers,Claudia Heldt,Jenny Meinhardt,Franziska Schmidt,Yasmina Rodriguez-Sillke,Yasmina Rodriguez-Sillke,Désirée Kunkel,Michael Schumann,Chotima Böttcher,Christiane Stahl-Hennig,Sefer Elezkurtaj,Christian Bojarski,Helena Radbruch,Victor M. Corman,Thomas Schneider,Christoph Loddenkemper,V. Moos,Carl Weidinger,Anja A. Kühl,Britta Siegmund +20 more
TL;DR: In this article, the authors used qRT-PCR and immunohistochemistry to detect SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa and identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8+ T cells as well as epithelial apoptosis and subsequent regenerative proliferation.
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Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22.
Deborah Delbue,Lydia Lebenheim,Danielle Cardoso-Silva,Violaine Dony,Susanne M. Krug,Jan F. Richter,Subhakankha Manna,Melba Muñoz,Kerstin Wolk,Claudia Heldt,Markus M. Heimesaat,Robert Sabat,Britta Siegmund,Michael Schumann +13 more
TL;DR: In this article, the authors investigated IL-22-dependent mechanisms in the reprogramming of intestinal epithelia, and found that IECs exhibited a barrier defect after IEC exposure.
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The combination of clinical parameters and immunophenotyping of intraepithelial lymphocytes allows to assess disease severity in refractory celiac disease.
Federica Branchi,Jakob Johann Wiese,Claudia Heldt,Subhakankha Manna,Violaine Dony,Christoph Loddenkemper,Christian Bojarski,Britta Siegmund,O. Schneider,Severin Daum,Michael Hummel,Verena Moos,Michael Schumann +12 more
TL;DR: In this article , the authors investigated possible associations between clinical characteristics of refractory celiac disease patients and aberrant intraepithelial lymphocytes and evaluated the accuracy of immunophenotyping for the identification of high-risk this article .
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Uptake of Tropheryma whipplei by Intestinal Epithelia
Julian Friebel,Katina Schinnerling,Kathleen Weigt,Claudia Heldt,Anja Fromm,Christian Bojarski,Britta Siegmund,Hans-Jörg Epple,Judith Kikhney,Annette Moter,T. Schneider,Jörg-Dieter Schulzke,Verena Moos,Michael Schumann +13 more
TL;DR: In this article , Tropheryma whipplei (TW) is shown to be dynamin and caveolin-dependent but independent of clathrin-mediated endocytosis.
Journal ArticleDOI
P047 Osteopontin in colitis-associated carcinoma (CAC)
Subhakankha Manna,Maximilian Sehn,D Cardoso da Silva,Claudia Heldt,L. Horstkorte,Sefer Elezkurtaj,Britta Siegmund,Benjamin Weixler,Michael Hummel,Jörn Gröne,Mareike Schumann +10 more
TL;DR: In this paper , the authors used RNA isolation and Nanostring gene expression analysis to understand CAC carcinogenesis, using human samples from patients suffering from Crohn′s disease (CD), CD-associated CAC (CD-CAC), ulcerative colitis (UC), and UC-associated Crohn' s disease (UC) and further validated the findings in vitro.