C
Carla A. Da Silva
Researcher at AstraZeneca
Publications - 29
Citations - 2678
Carla A. Da Silva is an academic researcher from AstraZeneca. The author has contributed to research in topics: Stem cell factor & Asthma. The author has an hindex of 17, co-authored 27 publications receiving 2392 citations. Previous affiliations of Carla A. Da Silva include French Institute of Health and Medical Research & Yale University.
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Journal ArticleDOI
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
Chun Geun Lee,Carla A. Da Silva,Charles S. Dela Cruz,Farida Ahangari,Bing Ma,Min-Jong Kang,Chuan-Hua He,Seyedtaghi Takyar,Jack A. Elias +8 more
TL;DR: Levels of YKL-40 in the lung and serum are increased in asthma and other inflammatory and remodeling disorders and often correlate with disease severity, indicating understanding of the roles of C/CLPs in inflammation, tissue remodeling, and tissue injury in health and disease.
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Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis
Chun Geun Lee,Dominik Hartl,Gap Ryol Lee,Barbara Koller,Hiroshi Matsuura,Carla A. Da Silva,Myung Hyun Sohn,Lauren Cohn,Robert J. Homer,Alexander Kozhich,Alison A. Humbles,Jennifer Kearley,Anthony J. Coyle,Geoffrey L. Chupp,Jennifer L. Reed,Richard A. Flavell,Jack A. Elias +16 more
TL;DR: These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders.
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Chitin regulation of immune responses: an old molecule with new roles.
TL;DR: This work demonstrated that chitin has complex and size-dependent effects on innate and adaptive immune responses including the ability to recruit and activate innate immune cells and induce cytokine and chemokine production via a variety of cell surface receptors.
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Stem cell factor and its receptor c-Kit as targets for inflammatory diseases.
TL;DR: Data suggest that SCF/c-Kit may be a potential therapeutic target for the control of mast cell and eosinophil number and activation in inflammatory diseases.
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
TL;DR: Chitin contains size-dependent pathogen-associated molecular patterns that stimulate TLR2, dectin-1, and the mannose receptor, differentially activate NF-κB and spleen tyrosine kinase, and stimulate the production of pro- and anti-inflammatory cytokines.