J
Jack A. Elias
Researcher at Brown University
Publications - 335
Citations - 32637
Jack A. Elias is an academic researcher from Brown University. The author has contributed to research in topics: Inflammation & Interleukin 13. The author has an hindex of 89, co-authored 324 publications receiving 30415 citations. Previous affiliations of Jack A. Elias include Yale University & Veterans Health Administration.
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Journal ArticleDOI
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhou Zhu,Robert J. Homer,Robert J. Homer,Zhonde Wang,Qingsheng Chen,Gregory P. Geba,Gregory P. Geba,Jingming Wang,Yong Zhang,Jack A. Elias +9 more
TL;DR: The targeted pulmonary expression of IL-13 causes a mononuclear and eosinophilic inflammatory response, mucus cell metaplasia, airway fibrosis, eotaxin production, airways obstruction, and nonspecific AHR in transgene-positive animals.
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IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.
Sophie Molet,Qutayba Hamid,Francis Davoine,Esra Nutku,Rame Taha,Nathalie Pagé,Ron Olivenstein,Jack A. Elias,Jamila Chakir +8 more
TL;DR: The results, which demonstrate for the first time that eosinophils are a potential source of IL-17 within asthmatic airways, suggest that IL- 17 might have the potential to amplify inflammatory responses through the release of proinflammatory mediators such as alpha-chemokines.
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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman,Xiaozhu Huang,Laura L. Koth,Grace H.-F. Chang,Gregory Dolganov,Zhou Zhu,Jack A. Elias,Dean Sheppard,David J. Erle +8 more
TL;DR: The results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma, including airway hyperreactivity and mucus overproduction.
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Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Chun Geun Lee,Robert J. Homer,Zhou Zhu,Sophie Lanone,Xiaoman Wang,Victor Koteliansky,J. Michael Shipley,Philip Gotwals,Paul W. Noble,Qingsheng Chen,Robert M. Senior,Jack A. Elias +11 more
TL;DR: It is demonstrated that IL-13 is a potent stimulator and activator of TGF-β1 in vivo and that this activation is mediated by a plasmin/serine protease- and MMP-9–dependent and CD44-independent mechanism and that the fibrogenic effects of IL- 13 are mediated, in great extent, by this T GF-β pathway.
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Proceedings of the ATS Workshop on Refractory Asthma Current Understanding, Recommendations, and Unanswered Questions
Sally E. Wenzel,John V. Fahy,Charles G. Irvin,Stephen P. Peters,Sheldon L. Spector,Stanley J. Szefler,Thomas B. Casale,Michelle M. Cloutier,Jack A. Elias,Mark C. Liu,Virginia Taggert +10 more
TL;DR: The proceedings of an American Thoracic Society (ATS)-sponsored workshop are hoped to serve as an aid to begin to define, understand, and manage these refractory patients.