Carla F.S. Guazelli

TL;DR: Preclinical data indicate that pectin/casein polymer microcapsules loaded with 1 improved the anti-inflammatory and antioxidant effects of 1 compared to the nonencapsulated drug, and quercetin seems to be a promising active molecule in inflammatory bowel disease if provided with adequate controlled release.

TL;DR: This is the first report that HMC reduces inflammation and inflammatory pain by targeting TRPV1 (transient receptor potential vanilloid type 1) receptor activity, oxidative stress, cytokine production, and NF-κB activity, which suggests its potential applicability in inflammatory diseases.

TL;DR: To the knowledge, this is the first study demonstrating that diclofenac‐induced AKI increases NF‐&kgr;B activation, and that vinpocetine reduces the nephrotoxic effects of dicL ofenac.

TL;DR: Quercetin exerted anti-inflammatory, analgesic and antioxidant effects in experimental arthritis, suggesting quercet in is a possible candidate for arthritis treatment.

TL;DR: The well-established superoxide anion donor KO2 is a valuable tool for studying the mechanisms and pharmacological susceptibilities of superoxideAnion-triggered nociceptive and inflammatory responses ranging from mechanical and thermal hyperalgesia to overt pain-like behaviors, edema, and leukocyte recruitment.