Showing papers in "Chemico-Biological Interactions in 2015"

TL;DR: The aldo-keto reductase (AKR) protein superfamily contains >190 members that fall into 16 families and are found in all phyla and are now poised to be interrogated using modern genomic and informatics approaches to determine their association with human health and disease.

TL;DR: It is revealed that rutin may be a promising modulator in attenuating CP induced oxidative stress, inflammation and hepatotoxicity via targeting NFκB and MAPK pathway.

TL;DR: Myricitrin provided better hepatoprotection when compared to silymarin, which is consistent with its higher in vitro antioxidant potential.

TL;DR: Changes in intracellular redox status induced by CONP are partly attributed to the prooxidant activity of the nanoparticles, and low inhibitory potential of CONP in the other human cell lines tested indicates that CONP may be safe for human usage in industry and medicine.

TL;DR: Crocin protects rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative,Anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release.

TL;DR: SFSE-G showed anti-fibrotic efficacy executed through induction of Nrf2, which in turn may modulate anti-inflammatory molecules, inhibit fibrogenic molecules and decreased apoptosis to ameliorate BLM induced pulmonary fibrosis.

TL;DR: It is suggested that bare CoO NPs are a toxic for primary human immune cells that deals directly with human health and surface modification or surface functionalization may open the gateway for further use of CoONPs in different industrial use or in biomedical sciences.

TL;DR: Evidence is produced that the encapsulation of carvacrol in β-cyclodextrin can be useful for the development of new options for pain management, as well as spontaneous and palpation-induced nociception.

TL;DR: Naringin administration was able to protect against deterioration in striatum tissue, abrogate the change in antioxidant enzyme activities and suppressed the increase in MDA, PCO, NO and TNF-α concentrations, demonstrating the neuroprotective nature of Nar.

TL;DR: Analysis by enzyme kinetics and QTOF mass spectrometry demonstrates that DEAB is an irreversible inhibitor of ALDH1A2 and ALDH2 with apparent bimolecular rate constants of 2900 and 86,000 M(-1) s(-1), respectively.

TL;DR: This is the first report that HMC reduces inflammation and inflammatory pain by targeting TRPV1 (transient receptor potential vanilloid type 1) receptor activity, oxidative stress, cytokine production, and NF-κB activity, which suggests its potential applicability in inflammatory diseases.

TL;DR: This review focused on lipidomic applications in brain injury disease, cancer, metabolic disease, cardiovascular disease, respiratory disease and infectious disease to discover disease biomarkers and illustrate biochemical metabolic pathways.

TL;DR: The data presented here show the protective role of CA by its ability to counteract MG negative effects, and prevented MG-dependent neurotoxicity by activating the PI3K/Akt/Nrf2 signaling pathway and the antioxidant enzymes modulated by Nrf2 transcription factor.

TL;DR: A better understanding of RCS metabolism by oxidoreductases could lead to the development of novel therapeutic interventions to decrease oxidative injury in several disease states and to enhance resistance to ROS-induced toxicity.

TL;DR: The results suggest that CA protected against 6-OHDA-induced neurotoxicity is attributable to its anti-apoptotic and anti-oxidative action and the possible mechanisms of rosemary in the neuroprotection of PD.

TL;DR: The data showed that AP significantly suppressed the expressions of P2X7/NF-κB signal-related proteins and alleviated inflammatory reactions and it was assumed that AP might be a potential therapeutic candidate to treat arthritis.

TL;DR: This study demonstrated that SinA, SinB, SinC, SolA, SolB and SthA exhibited significant protective actions toward APAP-induced liver injury, which was partially associated with the inhibition of CYP-mediated APAP bioactivation.

TL;DR: Significantly increased total cholesterol, triglycerides and low- density lipoprotein cholesterol as well as decreased high-density lipop protein cholesterol were observed in diet-induced hyperlipidemic rats, highlighting the perturbation of lipid metabolism in diets with high fat diets.

TL;DR: Evidence shows PA to have cytotoxic, anticancer, antidiabetic, lipid lowering and aniteratogenic activities, and phytol may be considered as a new drug candidate.

TL;DR: Rutan-zinc(II), a flavonoid-metal complex, was synthesized and characterized by UV-VIS, FT-IR, elemental analysis and (1)H NMR and modulated the mitochondrial membrane potential and the expression of genes related to cell cycle progression, angiogenesis and apoptosis in Ehrlich ascites carcinoma model.

TL;DR: 4-PBA may be a therapeutic strategy to consider in preventing pressure-overload induced myocardial hypertrophy and interstitial fibrosis by selectively attenuating ER stress.

TL;DR: The results suggest that vinpocetine represents an important therapeutic approach to treat inflammation and pain induced by a gram-negative bacterial component by targeting NF-κB activation and NF-kkB-related cytokine production in macrophages.

TL;DR: It is found that Gambogic acid can markedly sensitize doxorubicin (DOX)-resistant breast cancer cells to DOX-mediated cell death and give rise to the possibility of applying GA as an anticancer agent for the purpose of combatingDOX- resistant breast cancer.

TL;DR: In this paper, the first human ALDH1A1 structure was presented, as the apo-enzyme and in complex with its cofactor NADH to a resolution of 1.75 and 2.1A, respectively.

TL;DR: It is demonstrated that GPHs contain bioactive peptides that possess significant hypoglycemic and antioxidant properties, and ameliorate renal damage in rats fed hypercaloric diet.

TL;DR: It is implicate that H2S can afford protection to rat kidneys against uranium-induced adverse effects through induction of antioxidant defense by activating Nrf2 pathway and reduction of inflammatory response by suppressing NF-κB pathway.

TL;DR: PAP was shown to exert a high antioxidant activity in vitro and a dose-dependent antiproliferative effect against LoVo cancer cells, and could increase the generation of intracellular ROS which was a critical mediator in PAP-induced cell growth inhibition.

TL;DR: The present review is an attempt to summarize the chemistry and biology of this molecule since its isolation in 1982, which embodies the isolation, structure elucidation, stereo chemical description, structural classification, chemical synthesis, structural modifications and antitumor evaluation reported till date.

TL;DR: Chrysin has the efficacy to reverse CCl4-stimulated liver fibrosis by inhibition of HSCs activation and proliferation through TGF-β1/Smad pathway and might offer the possibility to develop a new therapeutic drug, useful in treatment of chronic liver diseases.

TL;DR: The results demonstrate the therapeutic detoxification of CGA against AP-induced liver injury, and TLR3/4 and NFκB signaling pathway are involved in such process.