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Carla van Tienen
Researcher at Erasmus University Rotterdam
Publications - 25
Citations - 1072
Carla van Tienen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Population & Viral load. The author has an hindex of 13, co-authored 24 publications receiving 805 citations. Previous affiliations of Carla van Tienen include Medical Research Council.
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Journal ArticleDOI
Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study.
Alexander Schauwvlieghe,Bart J. A. Rijnders,Nele Philips,Rosanne Verwijs,Lore Vanderbeke,Carla van Tienen,Katrien Lagrou,Paul E. Verweij,Frank L. van de Veerdonk,Diederik Gommers,Peter E. Spronk,Dennis C J J Bergmans,Astrid Hoedemaekers,Eleni-Rosalina Andrinopoulou,Charlotte H S B van den Berg,Nicole P. Juffermans,Casper J Hodiamont,Alieke G. Vonk,Pieter Depuydt,Jerina Boelens,Joost Wauters +20 more
TL;DR: In this study, influenza was found to be independently associated with invasive pulmonary aspergillosis, along with a higher APACHE II score, male sex, and use of corticosteroids, and is associated with high mortality.
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Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village
Maarten F. Schim van der Loeff,Natasha Larke,Steve Kaye,Neil Berry,Koya Ariyoshi,Abraham Alabi,Carla van Tienen,Aleksandra Leligdowicz,Ramu Sarge-Njie,Zacharias da Silva,Assan Jaye,D. Ricard,T Vincent,Sarah Rowland Jones,Peter Aaby,Shabbar Jaffar,Hilton Whittle +16 more
TL;DR: A substantial proportion of HIV-2 infected subjects in this cohort have stable plasma viral load, and those with an undetectable viral load at study entry had a normal survival rate: strikingly, mortality in this group was similar to that of the general population.
Journal ArticleDOI
Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau.
Carla van Tienen,Maarten F. Schim van der Loeff,Syed M. A. Zaman,Tim Vincent,Ramu Sarge-Njie,Ingrid Peterson,Aleksandra Leligdowicz,Assan Jaye,Sarah Rowland-Jones,Peter Aaby,Hilton Whittle +10 more
TL;DR: HIV-1 incidence is stable, and its prevalence is increasing, whereas HIV-2 incidence and prevalence are both declining, in contrast with what has been observed in other sub-Saharan countries, HIV-1 prevalence is lower in younger age groups than older age groups.
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Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa
Louis-Marie Yindom,Aleksandra Leligdowicz,Maureen P. Martin,Xiaojiang Gao,Ying Qi,Syed M. A. Zaman,Syed M. A. Zaman,Maarten F. Schim van der Loeff,Carla van Tienen,Assan Jaye,Akum A. Aveika,Archibald Worwui,Mathurin Diatta,Tim Vincent,Hilton Whittle,Sarah Rowland-Jones,Robert Walton,Robert Walton,Mary Carrington,Mary Carrington +19 more
TL;DR: It is shown for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HCA*0801 is associated with susceptibility to infection, and the unique nature of the effects of HLA and HLA/KIR combinations on HIV- 2 immune responses relative to HIV-1 is emphasized.
Journal ArticleDOI
HTLV-1 and HIV-2 infection are associated with increased mortality in a rural west African community.
Carla van Tienen,Maarten F. Schim van der Loeff,Ingrid Peterson,Matthew Cotten,Sören Andersson,Birgitta G Holmgren,Tim Vincent,Thushan I de Silva,Thushan I de Silva,Sarah Rowland-Jones,Peter Aaby,Hilton Whittle +11 more
TL;DR: In this article, the authors compared mortality rates of HIV-1, HIV-2, and HTLV-1 infected subjects with those of retrovirus-uninfected people in a rural community in Guinea-Bissau.