Carmen Agustín-Pavón

TL;DR: It is found that CB1R blockade in male Fmr1 knockout (Fmr1−/y) mice through pharmacological and genetic approaches normalized cognitive impairment, nociceptive desensitization, susceptibility to audiogenic seizures, overactivated mTOR signaling and altered spine morphology, whereas pharmacological blockade of CB2R normalized anxiolytic-like behavior.

TL;DR: Zinc finger repression was tested at several levels, resulting in protein aggregate reduction, reduced decline in rotarod performance, and alleviation of clasping in R6/2 mice, establishing a proof-of-principle for synthetic transcription factor repressors in the brain.

TL;DR: A proposal is made for the complementary roles that the olfactory and vomeronasal systems play in intersexual attraction and in other forms of intra- or inter-species communication.

TL;DR: These results suggest that both the antOFC and vlPFC can downregulate fear and anxiety and, together, provide necessary but independent contributions to the top-down control of negative emotion.

TL;DR: The present work constitutes the first demonstration of the unconditioned reinforcing properties of involatile, male-derived chemical signals, likely detected by the vomeronasal organ, steroid-dependent chemical signals in mammals.