C
Cristina Fillat
Researcher at University of Barcelona
Publications - 123
Citations - 4268
Cristina Fillat is an academic researcher from University of Barcelona. The author has contributed to research in topics: Pancreatic cancer & Oncolytic virus. The author has an hindex of 32, co-authored 114 publications receiving 3810 citations. Previous affiliations of Cristina Fillat include University of Cantabria & Carlos III Health Institute.
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Journal ArticleDOI
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down’s syndrome
Xavier Altafaj,Mara Dierssen,Carmela Baamonde,Eulàlia Martí,Joana Visa,Jordi Guimerà,Marta Oset,Juan R. González,Jesús Flórez,Cristina Fillat,Xavier Estivill +10 more
TL;DR: Transgenic mice generated by overexpressing the full-length cDNA of Dyrk1A show alterations comparable with those found in the partial trisomy chromosome 16 murine models of DS and suggest a causative role of DYRK1A in mental retardation and in motor anomalies of DS.
Journal ArticleDOI
Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.
TL;DR: A large effort has been made with numerous different strategies to enhance HSVtk/GCV efficacy in cellular and in vivo models and very strong cytotoxic effects have been obtained.
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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand
Sylvia F. Boj,Johan H. van Es,Meritxell Huch,Vivian S. W. Li,Anabel José,Pantelis Hatzis,Michal Mokry,Andrea Haegebarth,Maaike van den Born,Pierre Chambon,Peter J. Voshol,Yuval Dor,Edwin Cuppen,Cristina Fillat,Hans Clevers +14 more
TL;DR: It is shown that removal of TCF4 from β cells does not affect their function, whereas manipulating TCF3 levels in the liver has major effects on metabolism, implying that TCF 4 directly activates metabolic genes and that inhibition of Wnt signaling may be beneficial in metabolic disease.
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Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.
Mireia Garriga-Canut,Carmen Agustín-Pavón,Carmen Agustín-Pavón,Frank Herrmann,Frank Herrmann,Aurora Sánchez,Mara Dierssen,Cristina Fillat,Mark Isalan,Mark Isalan +9 more
TL;DR: Zinc finger repression was tested at several levels, resulting in protein aggregate reduction, reduced decline in rotarod performance, and alleviation of clasping in R6/2 mice, establishing a proof-of-principle for synthetic transcription factor repressors in the brain.
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X-linked thrombocytopenia (XLT) due to WAS mutations: Clinical characteristics, long-term outcome, and treatment options
Michael H. Albert,Tanja C. Bittner,Shigeaki Nonoyama,Lucia Dora Notarangelo,Siobhan O. Burns,Kohsuke Imai,Teresa Espanol,Anders Fasth,Isabelle Pellier,Gabriele Strauss,Tomohiro Morio,Benjamin Gathmann,Jeroen G. Noordzij,Cristina Fillat,Manfred Hoenig,Michaela Nathrath,Alfons Meindl,Philipp Pagel,Uwe Wintergerst,Alain Fischer,Adrian J. Thrasher,Bernd H. Belohradsky,Hans D. Ochs +22 more
TL;DR: An analysis of the clinical outcome and molecular basis of patients with XLT shows excellent long-term survival but also a high probability of severe disease-related complications, which will allow better decision making when considering treatment options for individual patients withXLT.