Mara Dierssen

TL;DR: Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity and diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning.

TL;DR: Transgenic mice generated by overexpressing the full-length cDNA of Dyrk1A show alterations comparable with those found in the partial trisomy chromosome 16 murine models of DS and suggest a causative role of DYRK1A in mental retardation and in motor anomalies of DS.

TL;DR: Evidence is provided about the nonredundant, vital role of Dyrk1A and a conserved mode of action is suggested that determines normal growth and brain size in both mice and flies.

TL;DR: Examination of conditional Erbb4 mouse mutants found that deletion of ErbB4 from the two main classes of fast-spiking interneurons, chandelier and basket cells, causes relatively subtle but consistent synaptic defects, reinforcing the view that dysfunction of cortical fast- Spiking interneeurons might be central to the pathophysiology of schizophrenia.

TL;DR: In this article, the authors evaluated the behavior of 16 male Ts(17 16 )65Dn mice (TS) and 16 control mice (CO) compared to their CO littermates in the Morris water maze.