C
Carmen Nuzzo
Researcher at Pfizer
Publications - 35
Citations - 1247
Carmen Nuzzo is an academic researcher from Pfizer. The author has contributed to research in topics: Pancreatic cancer & Breast cancer. The author has an hindex of 16, co-authored 34 publications receiving 1137 citations.
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Journal ArticleDOI
PTEN: Multiple Functions in Human Malignant Tumors
Michele Milella,Italia Falcone,Fabiana Conciatori,Ursula Cesta Incani,Anais Del Curatolo,Nicola Inzerilli,Carmen Nuzzo,Vanja Vaccaro,Sabrina Vari,Francesco Cognetti,Ludovica Ciuffreda +10 more
TL;DR: The current understanding of the biological role of PTEN, how PTEN expression and activity are regulated, and the consequences ofPTEN dysregulation in human malignant tumors are discussed.
Journal ArticleDOI
Efficacy and safety of ipilimumab 3 mg/kg in patients with pretreated, metastatic, mucosal melanoma
Michele Del Vecchio,Lorenza Di Guardo,Paolo A. Ascierto,Antonio M. Grimaldi,Vanna Chiarion Sileni,Jacopo Pigozzo,Virginia Ferraresi,Carmen Nuzzo,Gaetana Rinaldi,Alessandro Testori,Pier Francesco Ferrucci,Paolo Marchetti,Federica De Galitiis,Paola Queirolo,Elena Tornari,Riccardo Marconcini,Luana Calabrò,Michele Maio +17 more
TL;DR: Ipilimumab may be a feasible treatment option in pretreated patients with metastatic mucosal melanoma, and warrants further investigation in prospective clinical trials.
Journal ArticleDOI
Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients
Virginia Ferraresi,Carmen Nuzzo,Carmine Zoccali,Ferdinando Marandino,Antonello Vidiri,Nicola Salducca,M. Zeuli,Diana Giannarelli,Francesco Cognetti,Roberto Biagini +9 more
TL;DR: The clinical outcome of a series of chordoma patients followed at Regina Elena National Cancer Centre of Rome from 2004 to 2008 is described.
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Clinical Implications of KRAS Mutations in Lung Cancer Patients Treated with Tyrosine Kinase Inhibitors: An Important Role for Mutations in Minor Clones
Antonio Marchetti,Michele Milella,Lara Felicioni,Federico Cappuzzo,Luciana Irtelli,Maela Del Grammastro,Mariagrazia Sciarrotta,Sara Malatesta,Carmen Nuzzo,Giovanna Finocchiaro,Bruno Perrucci,Donatella Carlone,Alain Gelibter,Anna Ceribelli,Andrea Mezzetti,Stefano Iacobelli,Francesco Cognetti,Fiamma Buttitta +17 more
TL;DR: KRAS mutations in minor clones have an important impact on response and survival of patients with lung adenocarcinoma treated with EGFR-TKI and the use of sensitive detection methods could allow to more effectively identify treatment-resistant patients.
Journal ArticleDOI
Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme.
Vanna Chiarion Sileni,Jacopo Pigozzo,Paolo A. Ascierto,Antonio M. Grimaldi,Michele Maio,Lorenza Di Guardo,Paolo Marchetti,Francesco De Rosa,Carmen Nuzzo,Alessandro Testori,Emilia Cocorocchio,Maria Grazia Bernengo,Michele Guida,Riccardo Marconcini,Barbara Merelli,Giorgio Parmiani,Gaetana Rinaldi,Massimo Aglietta,Marco Grosso,Paola Queirolo +19 more
TL;DR: Ipilimumab treatment was generally well tolerated and resulted in clinical benefit and extended survival in elderly patients treated at centres in Italy and the safety profile was consistent with that observed in the general population of the Italian EAP.