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Carmine Giorgio
Researcher at University of Parma
Publications - 41
Citations - 784
Carmine Giorgio is an academic researcher from University of Parma. The author has contributed to research in topics: Ephrin & Erythropoietin-producing hepatocellular (Eph) receptor. The author has an hindex of 16, co-authored 35 publications receiving 627 citations.
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Journal ArticleDOI
Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation
Carmine Giorgio,Iftiin Hassan Mohamed,Lisa Flammini,Elisabetta Barocelli,Matteo Incerti,Alessio Lodola,Massimiliano Tognolini +6 more
TL;DR: The identified lithocholic acid (LCA) as a competitive and reversible ligand inhibiting EphA2-ephrinA1 interaction (Ki = 49 µM) suggesting an interaction with a highly conserved region of Eph receptor family.
Journal ArticleDOI
Targeting Eph/ephrin system in cancer therapy.
TL;DR: The present review summarizes the most critical findings proposing the Eph/ephrin signaling system as a new target in molecularly targeted oncology.
Journal ArticleDOI
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.
Matteo Incerti,Massimiliano Tognolini,Simonetta Russo,Daniele Pala,Carmine Giorgio,Iftiin Hassan-Mohamed,Roberta Noberini,Elena B. Pasquale,Paola Vicini,Silvia Piersanti,Silvia Rivara,Elisabetta Barocelli,Marco Mor,Alessio Lodola +13 more
TL;DR: The design and synthesis of an extended set of LCA derivatives obtained by conjugation of its carboxyl group with different α-amino acids are reported, indicating that the presence of a lipophilic amino acid side chain is fundamental to achieve good potencies.
Journal ArticleDOI
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties
Vigilio Ballabeni,Massimiliano Tognolini,Carmine Giorgio,Simona Bertoni,Renato Bruni,Elisabetta Barocelli +5 more
TL;DR: First evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil is provided, without damaging gastric mucosa, in in vitro and in vivo models of carrageenan-induced rat paw edema.
Journal ArticleDOI
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations
Iftiin Hassan-Mohamed,Carmine Giorgio,Matteo Incerti,Simonetta Russo,Daniele Pala,Elena B. Pasquale,Ilaria Zanotti,Paola Vicini,Elisabetta Barocelli,Silvia Rivara,Marco Mor,Alessio Lodola,Massimiliano Tognolini +12 more
TL;DR: The Eph receptor tyrosine kinases and their ephrin ligands are key players in tumorigenesis and many reports have correlated changes in their expression with a poor clinical prognosis in many solid tumours.