Carolin Reiser-Erkan

TL;DR: The activated stroma index (ASI) is a novel independent prognostic marker in PDAC in cases undergoing surgery and highlights the impact of the microenvironment in cancer progression and on patient survival.

TL;DR: Members of the Pancreatic Star Alliance discuss and consolidate current knowledge to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research.

TL;DR: Although PSCs are the dominant producers of VEGF and increase endothelial cell growth in vitro, in the peritumoral stroma, they contribute to the fibrotic/hypoxic milieu through abnormal extracellular matrix deposition and by amplifying endostatin production of cancer cells.

TL;DR: It has recently been shown that the activated stroma of pancreatic cancer is an independent prognostic marker with an impact on patient survival as much as the lymph node status of the cancer.

TL;DR: Ex expression of Pim-1 mRNA and protein increased significantly in pancreatic malignancies compared to benign, inflammatory and pre-malignant conditions and Hypoxia is a novel inducer of PIM-1 expression.