C
Carolina D. Rocha
Researcher at Universidade Federal de Minas Gerais
Publications - 16
Citations - 574
Carolina D. Rocha is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 9, co-authored 13 publications receiving 540 citations. Previous affiliations of Carolina D. Rocha include University of São Paulo & Oswaldo Cruz Foundation.
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Journal ArticleDOI
Pivotal Role of Interleukin-12 and Interferon-γ Axis in Controlling Tissue Parasitism and Inflammation in the Heart and Central Nervous System during Trypanosoma cruzi Infection
Vladimir Michailowsky,Vladimir Michailowsky,Neide M. Silva,Neide M. Silva,Carolina D. Rocha,Leda Quercia Vieira,Joseli Lannes-Vieira,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +8 more
TL;DR: The results suggest that the level of IFN-gamma deficiency is a major determinant of the site of reactivation of T. cruzi infection in immunocompromised host.
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Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis
Julio C. C. Lorenzi,Ana Paula Favaro Trombone,Carolina D. Rocha,Luciana P Almeida,Ricardo L Lousada,Thiago Malardo,Isabela C Fontoura,Renata Ariza Marques Rossetti,Ana Flávia Gembre,Aristóbolo M. Silva,Célio Lopes Silva,Arlete Aparecida Martins Coelho-Castelo +11 more
TL;DR: Vaccination of mice with a single dose of naked mRNA-Hsp65 through intranasal route was able to induce protection against subsequent challenge with virulent strain of Mycobacterium tuberculosis, showing a novel and efficient strategy to control experimental tuberculosis.
Journal Article
Recombinant viruses as tools to induce protective cellular immunity against infectious diseases
Carolina D. Rocha,Braulia Costa Caetano,Braulia Costa Caetano,Alexandre V. Machado,Oscar Bruna-Romero +4 more
TL;DR: This review will focus in particular on the development of new vaccination protocols against malaria and AIDS, both of which are major targets of the World Health Organization for vaccine development.
Journal ArticleDOI
Enhanced protective immunity against malaria by vaccination with a recombinant adenovirus encoding the circumsporozoite protein of Plasmodium lacking the GPI-anchoring motif.
Oscar Bruna-Romero,Carolina D. Rocha,Moriya Tsuji,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +4 more
TL;DR: It is shown that vaccination with an adenovirus recombinant carrying the anchoring motif-disrupted circumsporozoite gene resulted in significant increase of the number of interferon-gamma producing T cells and specific IgG2a isotype antibodies, ensuing more effective vaccination.
Journal ArticleDOI
Membrane Cholesterol Removal Changes Mechanical Properties of Cells and Induces Secretion of a Specific Pool of Lysosomes
Barbara Hissa,Bruno Pontes,Paula Magda da Silva Roma,Ana Paula Alves,Carolina D. Rocha,Thalita Marcolan Valverde,Pedro Henrique Nascimento Aguiar,Fernando P. Almeida,Allan J. Guimarães,Cristina Guatimosim,Aristóbolo M. Silva,Maria Cecilia Fernandes,Norma W. Andrews,Nathan B. Viana,Oscar N. Mesquita,Ubirajara Agero,Luciana O. Andrade +16 more
TL;DR: These data support the existence of at least two different pools of lysosomes with different exocytosis dynamics, one of which is directly mobilized for plasma membrane fusion after cholesterol removal, and also show for the first time that the amplitude of membrane-cytoskeleton fluctuation decreased during cholesterol sequestration.