M
Moriya Tsuji
Researcher at Aaron Diamond AIDS Research Center
Publications - 155
Citations - 9524
Moriya Tsuji is an academic researcher from Aaron Diamond AIDS Research Center. The author has contributed to research in topics: Immune system & Natural killer T cell. The author has an hindex of 50, co-authored 144 publications receiving 8882 citations. Previous affiliations of Moriya Tsuji include Rockefeller University & New York University.
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Journal ArticleDOI
Recognition of bacterial glycosphingolipids by natural killer T cells
Yuki Kinjo,Douglass Wu,Gisen Kim,Guo-Wen Xing,Michael A. Poles,Michael A. Poles,David D. Ho,Moriya Tsuji,Moriya Tsuji,Kazuyoshi Kawahara,Chi-Huey Wong,Mitchell Kronenberg +11 more
TL;DR: It is shown that most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bacteria that do not contain lipopolysaccharide, and that these cells might be useful in providing protection from bacteria that cannot be detected by pattern recognition receptors such as Toll-like receptor 4.
Journal ArticleDOI
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Yuki Kinjo,Emmanuel Tupin,Douglass Wu,Masakazu Fujio,Raquel Garcia-Navarro,Mohammed Rafii El Idrissi Benhnia,Mohammed Rafii El Idrissi Benhnia,Dirk M. Zajonc,Dirk M. Zajonc,Gil Ben-Menachem,Gary D. Ainge,Gavin F. Painter,Archana Khurana,Kasper Hoebe,Samuel M. Behar,Bruce Beutler,Ian A. Wilson,Moriya Tsuji,Timothy J. Sellati,Chi-Huey Wong,Mitchell Kronenberg +20 more
TL;DR: It is shown that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease, suggesting that NKT cell responses driven by T cell receptor–mediated glycolIPid recognition may provide protection against diverse pathogens.
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Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide
TL;DR: A synthetic C-glycoside analogue of α-GalCer, α-C-galactosylceramide, acts as natural killer T cell ligand in vivo, and stimulates an enhanced Th1-type response in mice, suggesting that α- C- GalCer may one day be an excellent therapeutic option for diseases resolved by Th1 -type responses.
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Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines
Gloria Gonzalez-Aseguinolaza,Luc Van Kaer,Cornelia C. Bergmann,James M. Wilson,John Schmieg,Mitchell Kronenberg,Toshinori Nakayama,Masaru Taniguchi,Yasuhiko Koezuka,Moriya Tsuji +9 more
TL;DR: This study shows that coadministration of α-GalCer with suboptimal doses of irradiated sporozoites or recombinant viruses expressing a malaria antigen greatly enhances the level of protective anti-malaria immunity in mice.
Journal ArticleDOI
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
TL;DR: The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.