V
Vladimir Michailowsky
Researcher at Oswaldo Cruz Foundation
Publications - 7
Citations - 580
Vladimir Michailowsky is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Chagas disease. The author has an hindex of 7, co-authored 7 publications receiving 554 citations. Previous affiliations of Vladimir Michailowsky include Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Pivotal Role of Interleukin-12 and Interferon-γ Axis in Controlling Tissue Parasitism and Inflammation in the Heart and Central Nervous System during Trypanosoma cruzi Infection
Vladimir Michailowsky,Vladimir Michailowsky,Neide M. Silva,Neide M. Silva,Carolina D. Rocha,Leda Quercia Vieira,Joseli Lannes-Vieira,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +8 more
TL;DR: The results suggest that the level of IFN-gamma deficiency is a major determinant of the site of reactivation of T. cruzi infection in immunocompromised host.
Journal ArticleDOI
Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-γ as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi.
André Talvani,André Talvani,Cristiana S Ribeiro,Julio Aliberti,Vladimir Michailowsky,Paula V.A. dos Santos,Silvane M. F. Murta,Alvaro J. Romanha,Igor C. Almeida,Joshua M. Farber,Joseli Lannes-Vieira,João Santana da Silva,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +13 more
TL;DR: Results indicate that regulation of IFN-gamma and chemokine expression, associated with decreased tissue parasitism, may be largely responsible for the control of inflammation and immunopathology observed in the cardiac tissue of animals infected with T. cruzi.
Journal ArticleDOI
Interleukin-12 Enhances In Vivo Parasiticidal Effect of Benznidazole during Acute Experimental Infection with a Naturally Drug-Resistant Strain of Trypanosoma cruzi
Vladimir Michailowsky,Silvane M. F. Murta,Silvane M. F. Murta,Leonardo Carvalho-Oliveira,Maria Elizabeth S Pereira,Ludmila Rodrigues Pinto Ferreira,Zigman Brener,Alvaro J. Romanha,Ricardo T. Gazzinelli +8 more
TL;DR: The results suggest that early activation of the cellular compartment of the immune system by IL-12 may favor in vivo Bz activity against T. cruzi, and indicate that a higher percentage of mice treated with Bz combined with rIL-12 than mice treatedwith Bz alone are cured.
Journal ArticleDOI
Humoral and Cellular Immune Responses to Trypanosoma cruzi-Derived Paraflagellar Rod Proteins in Patients with Chagas' Disease
Vladimir Michailowsky,Keith A. Luhrs,Manoel Otávio da Costa Rocha,David L. Fouts,Ricardo T. Gazzinelli,Jerry E. Manning +5 more
TL;DR: The results show that sera from both asymptomatic Chagas' disease patients (ACP) and cardiac ChagAs' disease Patients (CCP) have higher levels of antibodies to PFR than seras from NI, and the ability of PFR to elicit the production of gamma interferon (IFN-γ) by PBMC from patients with Chagos' disease is evaluated.
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TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-alpha blockade
Karina Kroll-Palhares,Jaline Coutinho Silverio,Andrea Alice da Silva,Vladimir Michailowsky,Ana Paula M.P. Marino,Neide M. Silva,Cristiano Marcelo Espinola Carvalho,Luzia Maria de Oliveira Pinto,Ricardo T. Gazzinelli,Joseli Lannes-Vieira +9 more
TL;DR: It is suggested that TNF/TNFR1 signaling promotes CD8-enriched myocarditis formation and heart tissue damage, implicating the TNF-alpha signaling pathway as a potential therapeutic target for control of T. cruzi-elicited cardiomyopathy.