C
Carolina Sousa
Researcher at University of Seville
Publications - 93
Citations - 4487
Carolina Sousa is an academic researcher from University of Seville. The author has contributed to research in topics: Gluten & Gluten free. The author has an hindex of 33, co-authored 83 publications receiving 3626 citations. Previous affiliations of Carolina Sousa include Centre national de la recherche scientifique & Pablo de Olavide University.
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Journal ArticleDOI
Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9.
Susana Sánchez-León,Javier Gil-Humanes,Carmen V. Ozuna,María J. Giménez,Carolina Sousa,Daniel F. Voytas,Francisco Barro +6 more
TL;DR: The low‐gluten, transgene‐free wheat lines described here could be used to produce low-gluten foodstuff and serve as source material to introgress this trait into elite wheat varieties.
Journal ArticleDOI
Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing
María de Lourdes Moreno,Angel Cebolla,Alba Muñoz-Suano,Carolina Carrillo-Carrión,Isabel Comino,Angeles Pizarro,Francisco Leon,Alfonso Rodríguez-Herrera,Carolina Sousa +8 more
TL;DR: GIP are detected in urine after gluten consumption, enabling a new and non-invasive method to monitor GFD compliance and transgressions and was convenient for clinical monitoring of patients with CD as well as for basic and clinical research applications including drug development.
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Enhanced metalloadsorption of bacterial cells displaying poly-His peptides.
TL;DR: In this article, the properties of Escherichia coli cells, acquired by cell surface presentation of one or two hexahistidine (His) clusters carried by the outer membrane LamB protein, have been examined.
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Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide
Belén Morón,Angel Cebolla,Hamid Manyani,Moisés Álvarez-Maqueda,Manuel Megías,María del Carmen Thomas,Manuel Carlos López,Carolina Sousa +7 more
TL;DR: Both ELISAs designed for use with the toxic gliadin 33-mer peptide suggested a high correlation between the presence of the peptide and the amount of cereal that was toxic to celiac disease patients, and the sensitivity was significantly higher than that of equivalent methods recognizing other gluten epitopes.
Journal ArticleDOI
Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide
Belén Morón,Belén Morón,Michael T. Bethune,Isabel Comino,Hamid Manyani,Marina Ferragud,Manuel Carlos López,Angel Cebolla,Chaitan Khosla,Carolina Sousa +9 more
TL;DR: The sensitivity and epitope preferences of the A1 antibody resulted to be useful to detect gluten relevant peptides to infer the potential toxicity of food for celiac patients as well as to monitor peptide modifications by transglutaminase 2 or glutenases.