C
Carmen V. Ozuna
Researcher at Spanish National Research Council
Publications - 13
Citations - 978
Carmen V. Ozuna is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gluten & Epitope. The author has an hindex of 8, co-authored 12 publications receiving 697 citations.
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Journal ArticleDOI
Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9.
Susana Sánchez-León,Javier Gil-Humanes,Carmen V. Ozuna,María J. Giménez,Carolina Sousa,Daniel F. Voytas,Francisco Barro +6 more
TL;DR: The low‐gluten, transgene‐free wheat lines described here could be used to produce low-gluten foodstuff and serve as source material to introgress this trait into elite wheat varieties.
Journal ArticleDOI
High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9.
Javier Gil-Humanes,Yanpeng Wang,Zhen Liang,Qiwei Shan,Carmen V. Ozuna,Susana Sánchez-León,Nicholas J. Baltes,Colby G. Starker,Francisco Barro,Caixia Gao,Daniel F. Voytas +10 more
TL;DR: High frequencies of GT using WDV-based DNA replicons will make it possible to edit complex cereal genomes without the need to integrate GT reagents into the genome.
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Targeting of prolamins by RNAi in bread wheat: effectiveness of seven silencing‐fragment combinations for obtaining lines devoid of coeliac disease epitopes from highly immunogenic gliadins
Francisco Barro,Julio C. M. Iehisa,María J. Giménez,María Dolores García-Molina,Carmen V. Ozuna,Isabel Comino,Carolina Sousa,Javier Gil-Humanes +7 more
TL;DR: The effectiveness of seven plasmid combinations, encompassing RNAi fragments from α-, γ-, ω-gliadins, and LMW glutenin subunits, for silencing the expression of different prolamin fractions are reported, raising the prospect of breeding wheat species with low levels of harmful gluten, and of achieving the important goal of developing nontoxic wheat cultivars.
Journal ArticleDOI
Diversification of the celiac disease α‐gliadin complex in wheat: a 33‐mer peptide with six overlapping epitopes, evolved following polyploidization
Carmen V. Ozuna,Julio C. M. Iehisa,María J. Giménez,Juan B. Alvarez,Carolina Sousa,Francisco Barro +5 more
TL;DR: These findings are important for reducing the incidence of CD by the breeding/selection of wheat varieties with low stimulatory capacity of T cells and advanced genome-editing techniques (TALENs, CRISPR) will be easier to implement on the small group of α-gliadins containing only immunogenic peptides.
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Target and Non-target Site Mechanisms Developed by Glyphosate-Resistant Hairy beggarticks (Bidens pilosa L.) Populations from Mexico.
Ricardo Alcántara-de la Cruz,Ricardo Alcántara-de la Cruz,Pablo Tomás Fernández-Moreno,Carmen V. Ozuna,Antonia M. Rojano-Delgado,Hugo E. Cruz-Hipolito,José A. Domínguez-Valenzuela,Francisco Barro,Rafael De Prado +8 more
TL;DR: Qualitative results confirmed the reduced 14C-glyphosate translocation in the resistant populations and confirmed the first glyphosate resistance case confirmed in hairy beggarticks in the world.