C
Caroline Menard
Researcher at Laval University
Publications - 71
Citations - 4912
Caroline Menard is an academic researcher from Laval University. The author has contributed to research in topics: AMPA receptor & Medicine. The author has an hindex of 27, co-authored 59 publications receiving 3312 citations. Previous affiliations of Caroline Menard include Icahn School of Medicine at Mount Sinai & Université du Québec à Trois-Rivières.
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Journal ArticleDOI
Social stress induces neurovascular pathology promoting depression.
Caroline Menard,Caroline Menard,Madeline L. Pfau,Georgia E. Hodes,Veronika Kana,Victoria X. Wang,Sylvain Bouchard,Aki Takahashi,Aki Takahashi,Meghan E. Flanigan,Hossein Aleyasin,Katherine B. LeClair,William G.M. Janssen,Benoit Labonté,Eric M. Parise,Zachary S. Lorsch,Sam A. Golden,Mitra Heshmati,Carol A. Tamminga,Gustavo Turecki,Matthew Campbell,Zahi A. Fayad,Cheuk Y. Tang,Miriam Merad,Scott J. Russo +24 more
TL;DR: Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.
Journal ArticleDOI
Sex-specific transcriptional signatures in human depression.
Benoit Labonté,Olivia Engmann,Immanuel Purushothaman,Caroline Menard,Junshi Wang,Chunfeng Tan,Joseph R. Scarpa,Gregory Moy,Yong-Hwee E. Loh,Michael E. Cahill,Zachary S. Lorsch,Peter J. Hamilton,Erin S. Calipari,Georgia E. Hodes,Orna Issler,Hope Kronman,Madeline L. Pfau,Aleksandar Obradovic,Yan Dong,Rachael L. Neve,Scott J. Russo,Andrew Kazarskis,Carol A. Tamminga,Naguib Mechawar,Naguib Mechawar,Gustavo Turecki,Gustavo Turecki,Bin Zhang,Li Shen,Eric J. Nestler +29 more
TL;DR: A major rearrangement of transcriptional patterns in MDD is shown, with limited overlap between males and females, and key regulators of sex-specific gene networks underlying MDD are identified and confirmed.
Journal ArticleDOI
Neuroimmune mechanisms of depression
TL;DR: Evidence in patients and in animal models of depression is examined that demonstrates how the peripheral immune system acts on the brain to alter an individual's response to stress, ultimately contributing to their vulnerability to mood disorders.
Journal ArticleDOI
Pathogenesis of depression: Insights from human and rodent studies
TL;DR: This review summarizes the most recent discoveries and insights for which parallel findings have been obtained in human depressed subjects and rodent models of mood disorders in order to examine the potential etiology of depression.
Journal ArticleDOI
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Georgia E. Hodes,Madeline L. Pfau,Immanuel Purushothaman,H. Francisca Ahn,Sam A. Golden,Daniel J. Christoffel,Jane Magida,Anna Brancato,Aki Takahashi,Meghan E. Flanigan,Caroline Menard,Hossein Aleyasin,Ja Wook Koo,Zachary S. Lorsch,Jian Feng,Mitra Heshmati,Minghui Wang,Gustavo Turecki,Rachel L. Neve,Bin Zhang,Li Shen,Eric J. Nestler,Scott J. Russo +22 more
TL;DR: It is reported that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in female mice, whereas males are resilient as they do not develop these behavioral abnormalities, and transcriptional analysis of nucleus accumbens revealed markedly different patterns of stress regulation of gene expression between the sexes.