V
Veronika Kana
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 15
Citations - 1631
Veronika Kana is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Cytotoxic T cell & Social stress. The author has an hindex of 9, co-authored 14 publications receiving 1077 citations.
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Journal ArticleDOI
Social stress induces neurovascular pathology promoting depression.
Caroline Menard,Caroline Menard,Madeline L. Pfau,Georgia E. Hodes,Veronika Kana,Victoria X. Wang,Sylvain Bouchard,Aki Takahashi,Aki Takahashi,Meghan E. Flanigan,Hossein Aleyasin,Katherine B. LeClair,William G.M. Janssen,Benoit Labonté,Eric M. Parise,Zachary S. Lorsch,Sam A. Golden,Mitra Heshmati,Carol A. Tamminga,Gustavo Turecki,Matthew Campbell,Zahi A. Fayad,Cheuk Y. Tang,Miriam Merad,Scott J. Russo +24 more
TL;DR: Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.
Journal ArticleDOI
Neuroimmune mechanisms of depression
TL;DR: Evidence in patients and in animal models of depression is examined that demonstrates how the peripheral immune system acts on the brain to alter an individual's response to stress, ultimately contributing to their vulnerability to mood disorders.
Journal ArticleDOI
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome
Aleksey Chudnovskiy,Arthur Mortha,Veronika Kana,Andrea Kennard,Juan David Ramírez,Juan David Ramírez,Adeeb Rahman,Romain Remark,Ilaria Mogno,Ruby Ng,Sasha Gnjatic,El-ad David Amir,Alexander Solovyov,Benjamin Greenbaum,Jose C. Clemente,Jeremiah J. Faith,Yasmine Belkaid,Michael E. Grigg,Miriam Merad +18 more
TL;DR: It is shown that the protozoan Tritrichomonas musculis activates the host epithelial inflammasome to induce IL-18 release, which increases mucosal host defenses at the cost of an increased risk of inflammatory disease.
Journal ArticleDOI
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Jun Wang,Jun Wang,Georgia E. Hodes,Hongxing Zhang,Song Zhang,Wei Zhao,Sam A. Golden,Weina Bi,Caroline Menard,Veronika Kana,Marylene Leboeuf,Marc Xie,Dana Bregman,Madeline L. Pfau,Meghan E. Flanigan,Adelaida Esteban-Fernández,Shrishailam Yemul,Ali Sharma,Lap Ho,Richard A. Dixon,Miriam Merad,Ming-Hu Han,Scott J. Russo,Giulio Maria Pasinetti,Giulio Maria Pasinetti +24 more
TL;DR: Two phytochemicals from bioactive dietary polyphenols are identified, shown to show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.
Journal ArticleDOI
CSF-1 controls cerebellar microglia and is required for motor function and social interaction
Veronika Kana,Fiona Desland,Maria Casanova-Acebes,Pinar Ayata,Ana Badimon,Elisa M. Nabel,Kazuhiko Yamamuro,Marjolein A. M. Sneeboer,I-li Tan,Meghan E. Flanigan,Samuel A. Rose,Christie Chang,Andrew Leader,Hortense Le Bourhis,Eric S. Sweet,Navpreet Tung,Aleksandra Wroblewska,Yonit Lavin,Peter See,Alessia Baccarini,Florent Ginhoux,Violeta Chitu,E. Richard Stanley,Scott J. Russo,Zhenyu Yue,Brian D. Brown,Alexandra L. Joyner,Lotje de Witte,Lotje de Witte,Hirofumi Morishita,Anne Schaefer,Miriam Merad +31 more
TL;DR: Kana et al. show CSF-1 signaling is critical for cerebellar microglial transcriptional identity and homeostasis, and that altering the CSf-1–CSF- 1R axis leads to motor and behavioral defects.