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Caroline R. Abbott
Researcher at Imperial College London
Publications - 27
Citations - 4552
Caroline R. Abbott is an academic researcher from Imperial College London. The author has contributed to research in topics: Hypothalamus & Cocaine and amphetamine regulated transcript. The author has an hindex of 23, co-authored 27 publications receiving 4425 citations. Previous affiliations of Caroline R. Abbott include Hammersmith Hospital.
Papers
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Journal ArticleDOI
Ghrelin Causes Hyperphagia and Obesity in Rats
Alison M. Wren,Caroline J. Small,Caroline R. Abbott,Waljit S. Dhillo,L. J. Seal,Mark Cohen,Rachel L. Batterham,Shahrad Taheri,Sarah Stanley,Mohammad A. Ghatei,Stephen R. Bloom +10 more
TL;DR: Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake.
Journal ArticleDOI
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Ulrika Andersson,Karin Filipsson,Caroline R. Abbott,Angela Woods,Kirsty L. Smith,Stephen R. Bloom,David Carling,Caroline J. Small +7 more
TL;DR: It is demonstrated that counter-regulatory hormones involved in appetite control regulate AMPK activity and that pharmacological activation of AMPK in the hypothalamus increases food intake, and that AMPK is identified as a novel target for anti-obesity drugs.
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The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway.
Caroline R. Abbott,Mariana P. Monteiro,Caroline J. Small,A Sajedi,Kirsty L. Smith,James R.C. Parkinson,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TL;DR: Findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake.
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Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3–36) on food intake
Caroline R. Abbott,Caroline J. Small,A Kennedy,Nicola M. Neary,A Sajedi,Mohammad A. Ghatei,Stephen R. Bloom +6 more
TL;DR: The studies suggest that the Y2R plays an important role in post-prandial satiety and provide further insight into the mechanisms of action of PYY, hypothesised to inhibit food intake via activation of the auto-inhibitory pre-synaptic neuropeptide Y (NPY) Y2 receptor (Y2R).
Journal ArticleDOI
Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats.
Sarah Stanley,Caroline J. Small,Kevin Murphy,E. Rayes,Caroline R. Abbott,L. J. Seal,David G.A. Morgan,D. Sunter,C. L. Dakin,Min Seon Kim,Richard G. Hunter,Michael J. Kuhar,M. A. Ghatei,Stephen R. Bloom +13 more
TL;DR: CART peptide may play a role in the control of pituitary function and in particular the hypothalamo-pituitary adrenal axis, according to the aims of this study.