S
Sylvie Breton
Researcher at Harvard University
Publications - 162
Citations - 9385
Sylvie Breton is an academic researcher from Harvard University. The author has contributed to research in topics: Epididymis & Apical membrane. The author has an hindex of 57, co-authored 154 publications receiving 8482 citations. Previous affiliations of Sylvie Breton include Université de Montréal & Laval University.
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Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
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Renal Vacuolar H+-ATPase
Carsten A. Wagner,Karin E. Finberg,Sylvie Breton,Vladimir Marshansky,Dennis Brown,John P. Geibel +5 more
TL;DR: The importance in final urinary acidification along the collecting system is highlighted by monogenic defects in two subunits (ATP6V0A4, ATP6V1B1) of the vacuolar H(+)-ATPase in patients with distal renal tubular acidosis.
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Acidification of the male reproductive tract by a proton pumping (H+)-ATPase.
TL;DR: It is shown that a vacuolar (H+)–ATPase is expressed at high levels on the luminal plasma membrane of specialized cells in the epididymis, which closely resemble acid–secreting kidney intercalated cells and that similar cells are also present in the vas deferens.
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Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
Núria M. Pastor-Soler,Valérie Beaulieu,Tatiana N. Litvin,Nicolas Da Silva,Yanqiu Chen,Dennis Brown,Jochen Buck,Lonny R. Levin,Sylvie Breton +8 more
TL;DR: A novel pathway for pH regulation linking the bicarbonate activated soluble adenylyl cyclase (sAC) to the vacuolar H+ATPase (V-ATPases) is reported, which may be a widespread mechanism that allows cells to sense and modulate extracellular pH.
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Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells
Richard Bouley,Sylvie Breton,Tian-Xiao Sun,Margaret McLaughlin,Ndona N. Nsumu,Herbert Y. Lin,Dennis A. Ausiello,Dennis Brown +7 more
TL;DR: A novel, cAMP-independent and cGMP-dependent pathway for AQP2 membrane insertion in renal epithelial cells is demonstrated.